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Controlled Clinical Trial
. 2017 Feb;24(1):34-40.
doi: 10.1007/s12350-015-0278-1. Epub 2015 Nov 5.

A useful and easy to develop combined stress test for myocardial perfusion imaging: Regadenoson and isometric exercise, preliminary results

Affiliations
Controlled Clinical Trial

A useful and easy to develop combined stress test for myocardial perfusion imaging: Regadenoson and isometric exercise, preliminary results

Lucile Janvier et al. J Nucl Cardiol. 2017 Feb.

Abstract

Background: Regadenoson, a selective A2a receptor agonist, is a vasodilator increasingly used in myocardial perfusion imaging. Adjunction of isometric exercise is a simple method that could improve side effect profile while providing better image quality.

Methods: Patients undergoing SPECT MPI were prospectively enrolled in handgrip-Regadenoson (HG-Reg test, N = 20) and Regadenoson (Reg) stress test (N = 40). Investigator blinded to stress test analyzed clinical data and images.

Results: Heart rate (HR) increase was statistically higher in the HG-Reg group (27 vs 22 bpm, P = .019). Decrease in SBP was less frequent in the HG-Reg group than in the Reg group (55% vs 85.5%, P = .005), there were less drops >10 mmHg (45% vs 77.7%, P = .012). During stress testing, fewer subjects reported at least one side effect in the HG-Reg compared to Reg group (70% vs 92.5%, P = .021). Images were more often classified as good in the HG-Reg group (75% vs 52.5% in the Reg group, P = .25).

Conclusions: Adjunction of handgrip exercise to Regadenoson administration is a well-tolerated and easy method, without loss of time. Furthermore, image quality seems to be better.

Keywords: Exercise stress; Regadenoson; myocardial perfusion imaging; vasodilator stress.

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Comment in

  • A helping hand for regadenoson tests.
    Kansal P, Holly TA. Kansal P, et al. J Nucl Cardiol. 2017 Feb;24(1):41-42. doi: 10.1007/s12350-015-0298-x. Epub 2015 Oct 22. J Nucl Cardiol. 2017. PMID: 26494646 No abstract available.

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