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. 2015 Oct 5:4:573.
doi: 10.1186/s40064-015-1350-7. eCollection 2015.

Long-term outcomes of colectomy surgery among patients with ulcerative colitis

Carl Brown  1 , Peter R Gibson  2 , Ailsa Hart  3 , Gilaad G Kaplan  4 , Sumesh Kachroo  5 , Qian Ding  6 , Emily Hautamaki  7 , Tao Fan  8 , Christopher M Black  5 , Xiaohan Hu  5 , Kathleen Beusterien  9
Affiliations

Long-term outcomes of colectomy surgery among patients with ulcerative colitis

Carl Brown et al. Springerplus. .

Abstract

The objective of this study was to evaluate long-term health-related quality of life outcomes among patients who had a colectomy within the previous 10 years. A cross-sectional survey was administered to consecutive patients ≥18 years of age with ulcerative colitis who had a colectomy within the last 10 years from centers in Canada, Australia, and the United Kingdom. Data were extracted from medical chart reviews to confirm selected self-reported patient characteristics. Of 351 survey respondents, 49 % were male and the median age was 40 years (interquartile range 30-52). Respondents were diagnosed with UC a median of 9.2 (5.7-15.1) years prior to the survey and first surgery occurred a median of 3.7 (2.1-5.8) years ago. Although most respondents (84 %) reported improved quality of life compared to the status before surgery, 81 % experienced problems in at least one of the following areas: depression, work productivity, restrictions in diet, body image, and sexual function. According to HADS scores, 30 and 17 % of survey respondents experienced anxiety and depression, respectively. Among moderate to severe UC patients pre-colectomy, 27 % of men and 28 % of women reported that their sexual life was worse now than before surgery. The mean EQ-5D utility index score overall was 0.79 (95 % confidence interval 0.77-0.81). Quality of life after colectomy for UC is generally good, but there are persistent quality of life issues that impact multiple domains, including psychological and sexual functioning.

Keywords: Colectomy; Quality of life, pouchitis/pouch failure; Survey; Ulcerative colitis.

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Figures

Fig. 1
Fig. 1
Flowchart of the Patients who were included in the statistical analysis
Fig. 2
Fig. 2
Proportion of LOCUS respondents with anxiety and depression between male and female patients
Fig. 3
Fig. 3
Proportion of LOCUS respondents with anxiety and depression between full-time employed and non-full-time employed patients*
Fig. 4
Fig. 4
Proportion of LOCUS respondents with detriments in health-related quality of life (HRQL) domains
See this image and copyright information in PMC

References

    1. Berndtsson I, Oresland T. Quality of life before and after proctocolectomy and IPAA in patients with ulcerative proctocolitis—a prospective study. Colorectal Dis. 2003;5:173–179. doi: 10.1046/j.1463-1318.2003.00455.x. - DOI - PubMed
    1. Bewtra M, Kilambi V, Fairchild AO, et al. Patient preferences for surgical versus medical therapy for ulcerative colitis. Inflamm Bowel Dis. 2014;20(1):103–114. doi: 10.1097/01.MIB.0000437498.14804.50. - DOI - PMC - PubMed
    1. Bouguen G, Roblin X, Bourreille A, et al. Infliximab for refractory ulcerative proctitis. Aliment Pharmacol Ther. 2010;31:1178–1185. doi: 10.1111/j.1365-2036.2010.04293.x. - DOI - PubMed
    1. Byrne CM, Tan KK, Young JM, et al. Patient and clinician preferences for surgical and medical treatment options in ulcerative colitis. Colorectal Dis. 2014;16(4):285–292. doi: 10.1111/codi.12538. - DOI - PubMed
    1. Dayan B, Turner D. Role of surgery in severe ulcerative colitis in the era of medical rescue therapy. World J Gastroenterol. 2012;18:3833–3838. doi: 10.3748/wjg.v18.i29.3833. - DOI - PMC - PubMed

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