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Comment
. 2015 Nov 5;17(5):503-4.
doi: 10.1016/j.stem.2015.10.007.

AMPK Keeps Tumor Cells from Starving to Death

Reuben J Shaw  1
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AMPK Keeps Tumor Cells from Starving to Death

Reuben J Shaw. Cell Stem Cell. .
Free article

Abstract

In this issue of Cell Stem Cell, Saito et al. (2015) examine how leukemia-initiating cells react to metabolic stress imposed by different tissue environments. They find that inhibition of the metabolic stress sensor AMP-activated protein kinase (AMPK) led to deranged glucose metabolism and redox homeostasis, resulting in reduced leukemic progression that was further attenuated by dietary restriction.

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