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. 2015 Nov 6:21:3395-400.
doi: 10.12659/msm.894774.

Platelet-to-Lymphocyte Ratio May Predict the Severity of Calcific Aortic Stenosis

Serkan Akdag  1 , Aytac Akyol  1 , Muntecep Asker  1 , Ramazan Duz  1 , Hasan Ali Gumrukcuoglu  1
Affiliations

Platelet-to-Lymphocyte Ratio May Predict the Severity of Calcific Aortic Stenosis

Serkan Akdag et al. Med Sci Monit. .

Abstract

Background: Platelet-to-lymphocyte ratio (PLR) is an emerging inflammatory indicator which is closely associated with adverse cardiovascular events. Therefore, we aimed to investigate the relationship between PLR and the severity of calcific aortic stenosis (AS).

Material and methods: The study was designed as a retrospective study. A total of 86 consecutive patients with calcific AS were divided into two groups as mild-to-moderate AS and severe AS according to the transaortic mean pressure gradient. PLR levels were calculated from the complete blood count (CBC).

Results: Platelet to lymphocyte ratio was significantly higher in severe and mild-to-moderate AS groups when compared to the control subjects (151±31.2, p<0.001, 138±28.8 vs. 126±26.5, p=0.008, respectively). In the subgroup analysis of AS patients, PLR was found to be higher in the severe AS group compared to mild-to-moderate group (p<0.001). A significant correlation was found between PLR and transaortic mean pressure gradient in patients with AS (r=0.421, p<0.001).

Conclusions: Our study results demonstrated that increased PLR correlates with the severity of calcific AS.

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Figures

Figure 1
Figure 1
Correlation between platelet/lymphocyte ratio and transaortic mean pressure gradient in patients with AS.
See this image and copyright information in PMC

References

    1. Burke A, Tavora F. Practical Cardiovascular Pathology. Wolters Kluwer, Lippincott Williams & Wilkins; 2011. pp. 309–12.
    1. Freeman RV, Otto CM. Spectrum of calcific aortic valve disease. Pathogenesis, disease progression, and treatment strategies, Circulation. 2005;111:3316–26. - PubMed
    1. Prohaska W, Zittermann A, Luth JU, et al. Prevalent platelet dysfunction in patients with aortic valve disease. J Heart Valve Dis. 2008;17(5):542–47. - PubMed
    1. Repossini A, Bloch D, Muneretto C, et al. Platelet reduction after stentless pericardial aortic valve replacement. Interact Cardiovasc Thorac Surg. 2012;14:434–38. - PMC - PubMed
    1. Fazio G, Caracciolo C, Barone R, et al. An unknown cause of aortic valve stenosis: polycythemia vera. J Thromb Thrombolysis. 2013;35(2):282–85. - PubMed

Supplementary concepts