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Multicenter Study
. 2015 Oct 23;29(16):2155-9.
doi: 10.1097/QAD.0000000000000819.

Off-label use of maraviroc in HIV-1-infected paediatric patients in clinical practice

Claudia Palladino  1 , María Luisa Navarro Gómez, Pere Soler-Palacín, María Isabel González-Tomé, Santiago J De Ory, María Espiau, Santiago Pérez Hoyos, Juan Antonio León-Leal, María Méndez, David Moreno-Pérez, Claudia Fortuny Guasch, Antoni Mur Sierra, Itziar Pocheville Guruceta, Santiago Moreno Guillén, Verónica Briz; CoRISpe Working Group
Affiliations
Multicenter Study

Off-label use of maraviroc in HIV-1-infected paediatric patients in clinical practice

Claudia Palladino et al. AIDS. .

Abstract

Maraviroc (MVC) is not approved for HIV-1-infected paediatric patients. This is the first assessment of the use of MVC-based salvage therapy in vertically HIV-1-infected paediatric patients in clinical settings. The results suggest that MVC-based salvage therapy is useful in children and adolescents with extensive resistance profile leading to maintained virological suppression in up to 88% of the patients with CCR5-tropic virus. The likelihood of treatment success might increase when MVC is combined with other active drugs.

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