Peroxisomes Get Loud: A Redox Antidote to Hearing Loss

Pablo Mardones¹, Claudio Hetz²

Affiliations

¹ Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile; Program of Cellular and Molecular Biology, Center for Molecular Studies of the Cell, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile.
² Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile; Program of Cellular and Molecular Biology, Center for Molecular Studies of the Cell, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile; FONDAP Center for Geroscience, Brain Health and Metabolism, University of Chile, Santiago, Chile; Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston MA 02115, USA. Electronic address: chetz@hsph.harvard.edu.

PMID: 26544930
DOI: 10.1016/j.cell.2015.10.060

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Peroxisomes Get Loud: A Redox Antidote to Hearing Loss

Pablo Mardones et al. Cell. 2015.

Free article

. 2015 Nov 5;163(4):790-1.

doi: 10.1016/j.cell.2015.10.060.

Authors

Pablo Mardones¹, Claudio Hetz²

Affiliations

¹ Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile; Program of Cellular and Molecular Biology, Center for Molecular Studies of the Cell, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile.
² Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile; Program of Cellular and Molecular Biology, Center for Molecular Studies of the Cell, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile; FONDAP Center for Geroscience, Brain Health and Metabolism, University of Chile, Santiago, Chile; Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston MA 02115, USA. Electronic address: chetz@hsph.harvard.edu.

PMID: 26544930
DOI: 10.1016/j.cell.2015.10.060

Abstract

Pejvakin (PJVK), a protein originally identified in Persian families with sensorineural hearing loss, regulates peroxisomal dynamics and the antioxidant defense triggered by noise exposure in hair cells and auditory neurons of the inner ear. These findings bring peroxisomes to the forefront of noise-induced hearing loss research.

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Hypervulnerability to Sound Exposure through Impaired Adaptive Proliferation of Peroxisomes.
Delmaghani S, Defourny J, Aghaie A, Beurg M, Dulon D, Thelen N, Perfettini I, Zelles T, Aller M, Meyer A, Emptoz A, Giraudet F, Leibovici M, Dartevelle S, Soubigou G, Thiry M, Vizi ES, Safieddine S, Hardelin JP, Avan P, Petit C. Delmaghani S, et al. Cell. 2015 Nov 5;163(4):894-906. doi: 10.1016/j.cell.2015.10.023. Cell. 2015. PMID: 26544938

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Peroxisomes Get Loud: A Redox Antidote to Hearing Loss

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Peroxisomes Get Loud: A Redox Antidote to Hearing Loss

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