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Comment
. 2015 Nov 5;163(4):794-5.
doi: 10.1016/j.cell.2015.10.057.

Aire Gets Company for Immune Tolerance

Ludger Klein  1
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Free article
Comment

Aire Gets Company for Immune Tolerance

Ludger Klein. Cell. .
Free article

Abstract

A specialized subset of epithelial cells in the thymus "promiscuously" transcribes thousands of peripheral genes to ensure that developing T cells can test their antigen receptors for dangerous autoreactivity. New findings by Takaba et al. indicate that the transcription factor Fezf2 acts independently of Aire in thymic epithelial cells to generate "genetic noise" for immunological tolerance.

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