Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2015 Nov 5;60(3):346-7.
doi: 10.1016/j.molcel.2015.10.015.

Human Gene Promoters Are Intrinsically Bidirectional

Robin Andersson  1 , Yun Chen  1 , Leighton Core  2 , John T Lis  3 , Albin Sandelin  4 , Torben Heick Jensen  5
Affiliations
Comment

Human Gene Promoters Are Intrinsically Bidirectional

Robin Andersson et al. Mol Cell. .
No abstract available

PubMed Disclaimer

Comment in

  • Perspectives on Unidirectional versus Divergent Transcription.
    Duttke SH, Lacadie SA, Ibrahim MM, Glass CK, Corcoran DL, Benner C, Heinz S, Kadonaga JT, Ohler U. Duttke SH, et al. Mol Cell. 2015 Nov 5;60(3):348-9. doi: 10.1016/j.molcel.2015.10.014. Mol Cell. 2015. PMID: 26545075 Free PMC article. No abstract available.

Comment on

  • Human promoters are intrinsically directional.
    Duttke SHC, Lacadie SA, Ibrahim MM, Glass CK, Corcoran DL, Benner C, Heinz S, Kadonaga JT, Ohler U. Duttke SHC, et al. Mol Cell. 2015 Feb 19;57(4):674-684. doi: 10.1016/j.molcel.2014.12.029. Epub 2015 Jan 29. Mol Cell. 2015. PMID: 25639469 Free PMC article.

References

    1. Almada AE, Wu X, Kriz AJ, Burge CB, Sharp PA. Promoter directionality is controlled by U1 snRNP and polyadenylation signals. Nature. 2013;499:360–363. - PMC - PubMed
    1. Andersson R, Refsing Andersen P, Valen E, Core LJ, Bornholdt J, Boyd M, Heick Jensen T, Sandelin A. Nuclear stability and transcriptional directionality separate functionally distinct RNA species. Nat Comms. 2014;5:5336. - PubMed
    1. Core LJ, Martins AL, Danko CG, Waters CT, Siepel A, Lis JT. Analysis of nascent RNA identifies a unified architecture of initiation regions at mammalian promoters and enhancers. Nat Genet. 2014;46:1311–1320. - PMC - PubMed
    1. Core LJ, Waterfall JJ, Lis JT. Nascent RNA sequencing reveals widespread pausing and divergent initiation at human promoters. Science. 2008;322:1845–1848. - PMC - PubMed
    1. Duttke SHC, Lacadie SA, Ibrahim MM, Glass CK, Corcoran DL, Benner C, Heinz S, Kadonaga JT, Ohler U. Human promoters are intrinsically directional. Mol Cell. 2015;57:674–684. - PMC - PubMed

Substances

LinkOut - more resources