Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Oct;19(4):1088-1094.
doi: 10.1007/s10120-015-0563-3. Epub 2015 Nov 6.

Clinical significance of the anterosuperior lymph nodes along the common hepatic artery identified by sentinel node mapping in patients with gastric cancer

Ayako Shimada  1 , Hiroya Takeuchi  2 , Satoshi Kamiya  1 , Kazumasa Fukuda  1 , Rieko Nakamura  1 , Tsunehiro Takahashi  1 , Norihito Wada  1 , Hirofumi Kawakubo  1 , Yoshiro Saikawa  1 , Tai Omori  1 , Tadaki Nakahara  3 , Masahiro Jinzaki  3 , Koji Murakami  3 , Yuko Kitagawa  1
Affiliations

Clinical significance of the anterosuperior lymph nodes along the common hepatic artery identified by sentinel node mapping in patients with gastric cancer

Ayako Shimada et al. Gastric Cancer. 2016 Oct.

Abstract

Background: The sentinel node (SN) concept is safely applied and validated in early gastric cancer. Gastric lymph nodes are divided into five basins with the main gastric arteries, and the anterosuperior lymph nodes with the common hepatic artery (No. 8a) are classified in the right gastric artery (r-GA) basin. Although No. 8a are considered to have lymphatic flow from the r-GA basin, there might be additional multiple lymphatic flows into No. 8a. The aim of this study is to analyze the lymphatic flows to No. 8a and to investigate the clinical significance of No. 8a as a sentinel node (SN No. 8a).

Methods: Four hundred and twenty-nine patients with cT1N0 or cT2N0 gastric cancer underwent SN mapping. We used technetium-99 tin colloid solution and blue dye as a tracer.

Results: We detected SN No. 8a in 35 (8.2 %) patients. In these patients, we detected SN No. 8a with SNs that belonged to the left gastric artery (l-GA) basin (66 %), right gastroepiploic artery (r-GEA) basin (54 %), and right gastric artery (r-GA) basin (46 %). In addition, celiac artery lymph nodes were detected as SNs significantly more frequently. Function-preserving surgery was performed significantly less often in patients with SN No. 8a (p =0.018).

Conclusions: We found that SN No. 8a seemed to have lymphatic flow not only from the r-GA basin, but also from the l-GA basin or r-GEA basin. When SN No. 8a are detected, we should be careful to perform function-preserving surgery, even in SN-negative cases.

Keywords: Function-preserving surgery; Gastric cancer; Lymph node 8a; Sentinel node; Sentinel node basin.

PubMed Disclaimer

References

    1. Cochrane Database Syst Rev. 2015 Aug 12;(8):CD001964 - PubMed
    1. Gastric Cancer. 2005;8(2):103-10 - PubMed
    1. J Clin Oncol. 2013 Oct 10;31(29):3704-10 - PubMed
    1. Gastric Cancer. 2011 Jun;14(2):113-23 - PubMed
    1. Br J Surg. 2003 Feb;90(2):178-82 - PubMed

MeSH terms

Substances