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Review
. 2015 Dec:46:21-33.
doi: 10.1016/j.mam.2015.09.003. Epub 2015 Nov 5.

Molecular pathophysiology of hepatic glucose production

Kfir Sharabi  1 , Clint D J Tavares  1 , Amy K Rines  1 , Pere Puigserver  2
Affiliations
Review

Molecular pathophysiology of hepatic glucose production

Kfir Sharabi et al. Mol Aspects Med. 2015 Dec.

Abstract

Maintaining blood glucose concentration within a relatively narrow range through periods of fasting or excess nutrient availability is essential to the survival of the organism. This is achieved through an intricate balance between glucose uptake and endogenous glucose production to maintain constant glucose concentrations. The liver plays a major role in maintaining normal whole body glucose levels by regulating the processes of de novo glucose production (gluconeogenesis) and glycogen breakdown (glycogenolysis), thus controlling the levels of hepatic glucose release. Aberrant regulation of hepatic glucose production (HGP) can result in deleterious clinical outcomes, and excessive HGP is a major contributor to the hyperglycemia observed in Type 2 diabetes mellitus (T2DM). Indeed, adjusting glycemia as close as possible to a non-diabetic range is the foremost objective in the medical treatment of patients with T2DM and is currently achieved in the clinic primarily through suppression of HGP. Here, we review the molecular mechanisms controlling HGP in response to nutritional and hormonal signals and discuss how these signals are altered in T2DM.

Keywords: glucagon; gluconeogenesis; glucose; insulin; liver.

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Figures

Figure 1
Figure 1. Metabolite flux in the control of HGP
A schematic overview of key enzymes and metabolites involved in the regulation of gluconeogenesis and hepatic glucose output (HGP). Flux through these metabolites is tightly regulated to control net gluconeogenesis or glycolysis. How insulin (blue) or glucagon (red) affect these key enzymes and metabolites is highlighted.
Figure 2
Figure 2. Transcriptional regulation of hepatic glucose output (HGP)
The transcriptional programs controlling the expression of gluconeogenic genes in hepatocytes are regulated by insulin and glucagon. Insulin, by activating Akt, leads to phosphorylation and nuclear exclusion of FoxO1 and subsequent suppression of gluconeogenic genes. Glucagon, by increasing intracellular cAMP levels, activates PKA and results in activation of CREB and subsequent activation of gluconeogenic genes.
See this image and copyright information in PMC

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