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Review
. 2015 Dec;49(4):251-7.
doi: 10.1007/s13139-015-0374-9. Epub 2015 Oct 2.

PET Radioligands for Imaging of Tau Pathology: Current Status

Yearn Seong Choe  1 , Kyung-Han Lee  1
Affiliations
Review

PET Radioligands for Imaging of Tau Pathology: Current Status

Yearn Seong Choe et al. Nucl Med Mol Imaging. 2015 Dec.

Abstract

The incidence of Alzheimer's disease (AD), a progressive neurodegenerative disorder, continues to soar with the rapid growth of the elderly population, thus creating an enormous social and economic burden. Although disease-modifying drugs to treat AD are not yet available, several candidate drugs are in clinical trials. Most of these drugs are expected to be effective at the early stages of the disease, and therefore the early and accurate diagnosis of AD will be a critical factor in efforts to improve the prognosis of patients with AD. This review focuses on lead radioligands developed to date and their preclinical data in order to facilitate the development of tau-specific positron emission tomography radioligands that are of great interest to the scientific community.

Keywords: Acetylcholinesterase; Alzheimer’s disease; PET; Radioligands; Tau; β-amyloid.

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Figures

Fig. 1
Fig. 1
Chemical structures of 11C-PIB and 18F-DDNP
Fig. 2
Fig. 2
Illustration of Aβ plaques and neurofibrillary tangles in brain tissue with AD
Fig. 3
Fig. 3
Chemical structures of 11C- and 18F-labeled lansoprazole and astemizole derivatives
Fig. 4
Fig. 4
Chemical structures of tau-specific radioligands
See this image and copyright information in PMC

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