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Review
. 2015 Aug 15;8(8):11896-904.
eCollection 2015.

Association between MMP-12-82A/G polymorphism and cancer risk: a meta-analysis

Luliang Liu  1 , Jinhuan Sun  2 , Guolin Li  1 , Boyu Gu  1 , Xiaolong Wang  1 , Huirong Chi  1 , Fulin Guo  1
Affiliations
Review

Association between MMP-12-82A/G polymorphism and cancer risk: a meta-analysis

Luliang Liu et al. Int J Clin Exp Med. .

Abstract

Background: Numerous studies have focused on the association between MMP-12-82A>G polymorphism and cancer risk, but produced inconsistent results. Therefore, we performed a meta-analysis of case-control study to evaluate the association of MMP-12-82A>G polymorphism and cancer risk.

Methods: A systematic literature search was conducted among PubMed, Web of Science, Science Direct, China National Knowledge Infrastructure (CNKI) and Wangfang databases updated on May 1st, 2015. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the strength of association between this polymorphism and cancer risk.

Results: A total of seventeen case-control studies with 7,450 cases and 7,348 controls were identified and analyzed. Overall, there was no statistically significant association between MMP-12-82A>G polymorphism and increased risk of cancer under all genetic models. Subgroup analysis by ethnicity observed that there is no strong relationship between MMP-12-82A>G polymorphism and cancer risk among Asian and European populations. Furthermore, stratified analysis based on the source of control revealed no statistically significant association between MMP-12-82A>G polymorphism and cancer risk either in hospital-based or population-based studies. However, when we stratified analysis based on cancer type, significant association was found in ovarian cancer, but not in other types of cancer.

Conclusion: This meta-analysis suggests that MMP-12-82A>G polymorphism is not significantly associated with overall cancer risk. However, MMP-12-82A>G polymorphism may increase the susceptibility to ovarian cancer.

Keywords: Matrix metalloproteinases-12; cancer risk; meta-analysis; polymorphism.

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Figures

Figure 1
Figure 1
Search strategy of the studies included in this meta-analysis.
Figure 2
Figure 2
Forest plot of ORs for the association of MMP-12-82A>G polymorphism with cancer risk under heterozygous model (GA vs. AA).
Figure 3
Figure 3
Begg’s funnel plot of the association between MMP-12-82A>G polymorphism and cancer risk under heterozygous model (GA vs. AA). Circles represent the weight of studies.
See this image and copyright information in PMC

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