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. 2015 Aug 15;8(8):12661-73.
eCollection 2015.

Peroxisome proliferator-activated receptor gamma (PPARG) rs1801282 C>G polymorphism is associated with cancer susceptibility in asians: an updated meta-analysis

Yafeng Wang  1 , Yu Chen  2 , Heping Jiang  3 , Weifeng Tang  4 , Mingqiang Kang  4 , Tianyun Liu  5 , Zengqing Guo  2 , Zhiqiang Ma  6
Affiliations

Peroxisome proliferator-activated receptor gamma (PPARG) rs1801282 C>G polymorphism is associated with cancer susceptibility in asians: an updated meta-analysis

Yafeng Wang et al. Int J Clin Exp Med. .

Abstract

Peroxisome proliferator-activated receptor gamma (PPARG) is related to inflammation and plays an important role in the development of cancer. PPARG rs1801282 C>G polymorphism might influence the risk of cancer by regulating production of PPARG gene. Hence, a comprehensive meta-analysis was conducted to explore the association of PPARG rs1801282 C>G polymorphism with cancer susceptibility. An extensive search of PubMed and Embase databases for all relevant publications was carried out. A total of 38 publications with 16,844 cancer cases and 23,736 controls for PPARG rs1801282 C>G polymorphism were recruited in our study. Our results indicated that PPARG rs1801282 C>G variants were associated with an increased cancer risk in Asian populations and gastric cancer. In summary, the findings suggest that PPARG rs1801282 C>G polymorphism may play a crucial role in malignant transformation and the development of cancer.

Keywords: Cancer; meta-analysi; peroxisome proliferator-activated receptor gamma; polymorphism.

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Figures

Figure 1
Figure 1
Flow diagram of included and excluded process.
Figure 2
Figure 2
Meta-analysis with a fixed-effect for the association of cancer risk with the PPARG rs1801282 C>G polymorphism in Asians (allele comparing model).
Figure 3
Figure 3
For PPARG rs1801282 C>G polymorphism, Begg’s funnel plot analysis for publication bias (allele comparing model).
Figure 4
Figure 4
For PPARG rs1801282 C>G polymorphism, Filled funnel plot of meta-analysis (allele comparing model).
See this image and copyright information in PMC

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