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. 1977 Feb;74(2):579-81.
doi: 10.1073/pnas.74.2.579.

Chemical transformation of rat cells infected with xenotropic type-C RNA virus and its suppression by virus-specific antiserum

P J Price, W A Suk, R L Peters, R V Gilden, R J Huebner

Chemical transformation of rat cells infected with xenotropic type-C RNA virus and its suppression by virus-specific antiserum

P J Price et al. Proc Natl Acad Sci U S A. 1977 Feb.

Abstract

Fischer rat embryo cells infected with xenotropic mouse type-C RNA viruses isolated from either NIH Swiss mice or C57L inbred mice were transformed by 4-nitroquinoline oxide or 3-methylcholanthrene under conditions in which neither treatment alone sufficed to induce transformation. Transformation was dependent on the presence of actively growing virus at the time of chemical treatment. Specific antibody to xenotropic virus neutralized the virus and inhibited malignant transformation by 3-methylcholanthrene.

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