Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Jul;57(7):815-21.
doi: 10.1177/0284185115610931. Epub 2015 Nov 8.

Lesions with unclear malignant potential (B3) after minimally invasive breast biopsy: evaluation of vacuum biopsies performed in Switzerland and recommended further management

Camilla Saladin  1 , Harald Haueisen  2 , Gert Kampmann  3 , Christian Oehlschlegel  4 , B Seifert  5 , Luzi Rageth  6 , Christoph Rageth  7 , S Stadlmann  8 , Rahel A Kubik-Huch  9 ; MIBB Group
Affiliations

Lesions with unclear malignant potential (B3) after minimally invasive breast biopsy: evaluation of vacuum biopsies performed in Switzerland and recommended further management

Camilla Saladin et al. Acta Radiol. 2016 Jul.

Abstract

Background: Histopathological B3 lesions after minimal invasive breast biopsy (VABB) are a particular challenge for the clinician, as there are currently no binding recommendations regarding the subsequent procedure.

Purpose: To analyze all B3 lesions, diagnosed at VABB and captured in the national central Swiss MIBB database and to provide a data basis for further management in this subgroup of patients.

Material and methods: All 9,153 stereotactically, sonographically, or magnetic resonance imaging (MRI)-guided vacuum-assisted breast biopsies, performed in Switzerland between 2009 and 2011, captured in a central database, were evaluated. The rate of B3 lesions and the definitive pathological findings in patients who underwent surgical resection were analyzed.

Results: The B3 rate was 17.0% (1532 of 9000 biopsies with B classification). Among the 521 lesions with a definitive postoperative diagnosis, the malignancy rate (invasive carcinoma or DCIS) was 21.5%. In patients with atypical ductal hyperplasia, papillary lesions, flat epithelial atypia, lobular neoplasia, and radial scar diagnosed by VABB, the malignancy rates were 25.9%, 3.1%, 18.3%, 26.4%, and 11.1%, respectively.

Conclusion: B3 lesions, comprising 17%, of all analyzed biopsies, were common and the proportion of malignancies in those lesions undergoing subsequent surgical excision was high (21.5%).

Keywords: B3 lesion; Breast cancer; ductal carcinoma in situ (DCIS); invasive carcinoma; uncertain malignant potential; vacuum-assisted breast biopsy.

PubMed Disclaimer

Figures

Fig. 1.
Fig. 1.
Data collection and data management flow chart of all patients in the database and distribution of B classification.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Park HL, Kim LS. The current role of vacuum assisted breast biopsy system in breast disease. J Breast Cancer 2011; 14: 1–7. - PMC - PubMed
    1. Ellis IO, Michell M, Pinder SE, et al. Guidelines for non-operative diagnostic procedures and reporting in breast cancer screening, London: NHSBSP, 2001.
    1. Andreu FJ, Sáez A, Sentís M, et al. Breast core biopsy reporting categories–An internal validation in a series of 3054 consecutive lesions. Breast 2007; 16: 94–101. - PubMed
    1. Zenklusen, Dirnhofer, Bubendorf, et al. Qualitätsrichtlinien der schweizerischen Gesellschaft für Pathologie SGPath [in German]. 2011. Available at: http://www.sgpath.ch/docs/QR_SGPath_DE_2011.pdf.
    1. Köchli O R, Rageth J C, Brun del Re R, et al. Bildgesteuerte minimalinvasive Mammaeingriffe: Konsensusstatements für die Schweizerische Gesellschaft für Senologie (SGS) und die Arbeitsgruppe Bildgesteuerte minimalinvasive Mammaeingriffe [in German]. Senologie - Zeitschrift für Mammadiagnostik und therapie 2009;6:181–184. Available at: http://www.mibb.ch/Documents/Seno_3-09_S181-184_Rageth.aspx.

LinkOut - more resources