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. 1977 Feb;74(2):725-9.
doi: 10.1073/pnas.74.2.725.

Thymosin alpha1: isolation and sequence analysis of an immunologically active thymic polypeptide

A L Goldstein, T L Low, M McAdoo, J McClure, G B Thurman, J Rossio, C Y Lai, D Chang, S S Wang, C Harvey, A H Ramel, J Meienhofer

Thymosin alpha1: isolation and sequence analysis of an immunologically active thymic polypeptide

A L Goldstein et al. Proc Natl Acad Sci U S A. 1977 Feb.

Abstract

The amino acid sequence of a biologically active polypeptide isolated from calf thymus, termed thymosin alpha1, has been determined. Thymosin alpha1 is a heat stable, highly acidic molecule composed of 28 amino acid residues. This peptide is one of several present in thymosin fraction 5 that may participate in the regulation, differentiation and function of thymus-dependent lymphocytes (T cells). A nomenclature for the family of polypeptides present in thymosin fraction 5 is suggested.

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References

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