doi: 10.1073/pnas.74.2.725.
Thymosin alpha1: isolation and sequence analysis of an immunologically active thymic polypeptide
- PMID: 265536
- PMCID: PMC392366
- DOI: 10.1073/pnas.74.2.725
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Thymosin alpha1: isolation and sequence analysis of an immunologically active thymic polypeptide
Proc Natl Acad Sci U S A.
1977 Feb.
Abstract
The amino acid sequence of a biologically active polypeptide isolated from calf thymus, termed thymosin alpha1, has been determined. Thymosin alpha1 is a heat stable, highly acidic molecule composed of 28 amino acid residues. This peptide is one of several present in thymosin fraction 5 that may participate in the regulation, differentiation and function of thymus-dependent lymphocytes (T cells). A nomenclature for the family of polypeptides present in thymosin fraction 5 is suggested.
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