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. 2013:2013:678132.
doi: 10.1155/2013/678132. Epub 2013 Mar 28.

Study on Mixed Solvency Concept in Formulation Development of Aqueous Injection of Poorly Water Soluble Drug

Shailendra Singh Solanki  1 , Love Kumar Soni  1 , Rajesh Kumar Maheshwari  2
Affiliations

Study on Mixed Solvency Concept in Formulation Development of Aqueous Injection of Poorly Water Soluble Drug

Shailendra Singh Solanki et al. J Pharm (Cairo). 2013.

Abstract

In the present investigation, mixed-solvency approach has been applied for the enhancement of aqueous solubility of a poorly water- soluble drug, zaltoprofen (selected as a model drug), by making blends (keeping total concentrations 40% w/v, constant) of selected water-soluble substances from among the hydrotropes (urea, sodium benzoate, sodium citrate, nicotinamide); water-soluble solids (PEG-4000, PEG-6000); and co-solvents (propylene glycol, glycerine, PEG-200, PEG-400, PEG-600). Aqueous solubility of drug in case of selected blends (12 blends) ranged from 9.091 ± 0.011 mg/ml-43.055 ± 0.14 mg/ml (as compared to the solubility in distilled water 0.072 ± 0.012 mg/ml). The enhancement in the solubility of drug in a mixed solvent containing 10% sodium citrate, 5% sodium benzoate and 25 % S cosolvent (25% S cosolvent contains PEG200, PEG 400, PEG600, Glycerine and Propylene glycol) was more than 600 fold. This proved a synergistic enhancement in solubility of a poorly water-soluble drug due to mixed cosolvent effect. Each solubilized product was characterized by ultraviolet and infrared techniques. Various properties of solution such as pH, viscosity, specific gravity and surface tension were studied. The developed formulation was studied for physical and chemical stability. This mixed solvency shall prove definitely a boon for pharmaceutical industries for the development of dosage form of poorly water soluble drugs.

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Figures

Figure 1
Figure 1
Structure of zaltoprofen.
Figure 2
Figure 2
UV spectra of zaltoprofen in distilled water.
Figure 3
Figure 3
UV spectra of zaltoprofen in glycerin.
Figure 4
Figure 4
UV spectra of zaltoprofen in nicotinamide.
Figure 5
Figure 5
UV spectra of zaltoprofen in PEG 200.
Figure 6
Figure 6
UV spectra of zaltoprofen in PEG 400.
Figure 7
Figure 7
UV spectra of zaltoprofen in PEG 600.
Figure 8
Figure 8
UV spectra of zaltoprofen in Propylene glycol.
Figure 9
Figure 9
UV spectra of zaltoprofen in sodium citrate.
Figure 10
Figure 10
UV spectra of zaltoprofen in urea.
Figure 11
Figure 11
UV spectra of zaltoprofen in sodium benzoate.
Figure 12
Figure 12
FTIR spectrum of zaltoprofen.
Figure 13
Figure 13
FTIR spectrum of zaltoprofen with all the solubilizers.
See this image and copyright information in PMC

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