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. 2015 Sep 30;5(3):375-85.
doi: 10.1159/000439043. eCollection 2015 Sep-Dec.

Hypertensive Disorders of Pregnancy Appear Not to Be Associated with Alzheimer's Disease Later in Life

Carolien N H Abheiden  1 , Rebecca van Doornik  1 , Annet M Aukes  1 , Wiesje M van der Flier  2 , Philip Scheltens  3 , Christianne J M de Groot  1
Affiliations

Hypertensive Disorders of Pregnancy Appear Not to Be Associated with Alzheimer's Disease Later in Life

Carolien N H Abheiden et al. Dement Geriatr Cogn Dis Extra. .

Abstract

Background: After hypertensive disorders of pregnancy, more subjective cognitive complaints and white matter lesions are reported compared to women after normal pregnancies. Both have a causal relationship with Alzheimer's disease (AD).

Aim: To investigate if women whose pregnancy was complicated by hypertensive disorders have an increased risk of AD.

Methods: A case-control study in women with AD from the Alzheimer Center of the VU University Medical Center Amsterdam and women without AD. Paper and telephone surveys were performed.

Results: The response rate was 85.2%. No relation between women with (n = 104) and without AD (n = 129) reporting pregnancies complicated by hypertensive disorders (p = 0.11) was found. Women with early-onset AD reported hypertensive disorders of pregnancy more often (p = 0.02) compared to women with late-onset AD.

Conclusion: A reported history of hypertensive disorders of pregnancy appears not to be associated with AD later in life.

Keywords: Alzheimer's disease; Early-onset dementia; Magnetic resonance imaging; Preeclampsia; Pregnancy-induced hypertension.

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Figures

Fig. 1
Fig. 1
Study flow diagram.
See this image and copyright information in PMC

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