Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Oct;9(10):BC08-11.
doi: 10.7860/JCDR/2015/15132.6684. Epub 2015 Oct 1.

Heart-Type Fatty Acid Binding Protein: A Better Cardiac Biomarker than CK-MB and Myoglobin in the Early Diagnosis of Acute Myocardial Infarction

Anand K Pyati  1 , Basavaraj B Devaranavadagi  2 , Sanjeev L Sajjannar  3 , Shashikant V Nikam  4 , Mohd Shannawaz  5 , Sudharani  6
Affiliations

Heart-Type Fatty Acid Binding Protein: A Better Cardiac Biomarker than CK-MB and Myoglobin in the Early Diagnosis of Acute Myocardial Infarction

Anand K Pyati et al. J Clin Diagn Res. 2015 Oct.

Abstract

Background: Early diagnosis and therapeutic intervention can improve the outcome of acute myocardial infarction (AMI). However, there are no satisfactory cardiac biomarkers for the diagnosis of AMI within 6 hours of onset of symptoms. Among novel biochemical markers of AMI, heart-type fatty acid binding protein (H-FABP) is of particular interest.

Aim: To compare the diagnostic value of H-FABP with that of CK-MB and myoglobin in suspected AMI patients within first 6 hours after the onset of symptoms.

Settings and design: The study includes 40 AMI cases and 40 non-cardiac chest pain otherwise healthy controls. The cases and controls were further divided into 2 groups depending on the time since chest pain as those subjects within 3 hours and those between 3-6 hours of onset of chest pain.

Materials and methods: In all the cases and controls, serum H-FABP, CK-MB and myoglobin concentrations were measured by Immunoturbidimetric method, immuno-inhibition method and Chemiluminescence immunoassay respectively.

Statistical analysis: Data is presented as mean ± SD values. Differences between means of two groups were assessed by Student t-test. Sensitivity, Specificity, Positive predictive value, Negative predictive values were calculated and ROC curve analysis was done to assess the diagnostic validity of each study parameter.

Results: The sensitivity, specificity, PPV, NPV of H-FABP were greater than CK-MB and myoglobin and ROC curve analysis demonstrated highest area under curve for H-FABP followed by myoglobin and CK-MB in patients with suspected AMI both within 3 hours and 3-6 hours after the onset of chest pain.

Conclusion: The diagnostic efficiency of H-FABP is greater than CK-MB and myoglobin for the early diagnosis of AMI within first 6 hours of chest pain. H-FABP can be used as an additional diagnostic tool for the early diagnosis of AMI.

Keywords: Chest pain; Diagnostic validity; Immunoturbidimetric method; ROC analysis; Sensitivity.

PubMed Disclaimer

Figures

[Table/Fig-4]:
[Table/Fig-4]:
ROC curve analysis of CK-MB, Myoglobin & H-FABP in 0-3 hour group
[Table/Fig-5]:
[Table/Fig-5]:
ROC curve analysis of CK-MB, Myoglobin & H-FABP in 3-6 hour group
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Flook N, Unge P, Agréus L, Karlson BW, Nilsson S. Clinical Review: Approach to managing undiagnosed chest pain – Could gastro-oesophageal reflux disease be the cause? Can Fam Physician. 2007;53:261–66. - PMC - PubMed
    1. Jena BN, Kadithi A. Study of Risk Factors Affecting the Survival Rate of Emergency Victims with “Chest Pain” as Chief Complaint. Indian J Community Med. 2009;34(4):293–97. - PMC - PubMed
    1. Gorenberg M, Marmor A, Rotstein H. Detection of chest pain of non-cardiac origin at the emergency room by a new non-invasive device avoiding unnecessary admission to hospital. Emerg Med J. 2005;22:486–89. - PMC - PubMed
    1. Alhashemi JA. Diagnostic accuracy of a bedside qualitative immunochromatographic test for acute myocardial infarction. Am J Emerg Med. 2006;24:149–55. - PubMed
    1. Adams J, Trent R, Rawles J. Earliest electrocardiographic evidence of myocardial infarction: implications for thrombolytic treatment. The GREAT Group. BMJ. 1993;307:409–13. - PMC - PubMed

LinkOut - more resources