Clinical and Haematological Effects of Hydroxyurea in β-Thalassemia Intermedia Patients

doi:10.7860/JCDR/2015/14807.6660

. 2015 Oct;9(10):OM01-3.

doi: 10.7860/JCDR/2015/14807.6660. Epub 2015 Oct 1.

Clinical and Haematological Effects of Hydroxyurea in β-Thalassemia Intermedia Patients

Bijan Keikhaei¹, Homayon Yousefi², Mohammad Bahadoram³

Affiliations

¹ Associate Professor, Department of Pediatrics Hematalogy Oncology, Health Research Institute, Research Centre of Thalassemia and Hemoglobinopathies, Ahvaz Jundishapur University of Medical Sciences , Ahvaz, Iran .
² Assistant Professor, Department of Pediatrics Hematalogy Oncology, Health Research Institute, Research Centre of Thalassemia and Hemoglobinopathies, Ahvaz Jundishapur University of Medical Sciences , Ahvaz, Iran .
³ Medical Student, Research Committee & Social Determinant of Health Research Center, Ahvaz Jundishapur University of Medical Sciences , Ahvaz, Iran .

PMID: 26557561
PMCID: PMC4625280
DOI: 10.7860/JCDR/2015/14807.6660

Clinical and Haematological Effects of Hydroxyurea in β-Thalassemia Intermedia Patients

Bijan Keikhaei et al. J Clin Diagn Res. 2015 Oct.

. 2015 Oct;9(10):OM01-3.

doi: 10.7860/JCDR/2015/14807.6660. Epub 2015 Oct 1.

Authors

Bijan Keikhaei¹, Homayon Yousefi², Mohammad Bahadoram³

Affiliations

¹ Associate Professor, Department of Pediatrics Hematalogy Oncology, Health Research Institute, Research Centre of Thalassemia and Hemoglobinopathies, Ahvaz Jundishapur University of Medical Sciences , Ahvaz, Iran .
² Assistant Professor, Department of Pediatrics Hematalogy Oncology, Health Research Institute, Research Centre of Thalassemia and Hemoglobinopathies, Ahvaz Jundishapur University of Medical Sciences , Ahvaz, Iran .
³ Medical Student, Research Committee & Social Determinant of Health Research Center, Ahvaz Jundishapur University of Medical Sciences , Ahvaz, Iran .

PMID: 26557561
PMCID: PMC4625280
DOI: 10.7860/JCDR/2015/14807.6660

Abstract

Introduction: It is well known that hydroxyurea (HU) impacts on clinical and haematologic indices in thalassemia. We aimed to evaluate the effect of hydroxyurea on clinical and haematological improvement in children with thalassemia intermedia.

Materials and methods: After the patients' enrollment in the study their data such as transfusion, hospitalization, spleen size, visit, total Hb, HbF levels, MCV and MCH were compared before and after treatment with HU 10 mg/kg/day/for one year.

Results: In patients with thalassemia intermedia, HU significantly diminished the rate of transfusion, hospitalization, spleen size and significantly increased Hb MCH, HbF and MCV. Moreover HU was well tolerated in our patients and we got no remarkable adverse effect.

Conclusion: We divulged hydroxyurea 10 mg/kg/day during one year. This significantly increased HbF, total haemoglobin, MCV, MCH, without any remarkable adverse events.

Keywords: Adverse effects; Fetal hemoglobin; Hematologic tests; Hospitalization; Spleen; Treatment outcome.

PubMed Disclaimer

Cited by

Evaluation of the combination therapy of hydroxyurea and thalidomide in β-thalassemia.
Ansari SH, Ansari I, Wasim M, Sattar A, Khawaja S, Zohaib M, Hussain Z, Adil SO, Ansari AH, Ansari UH, Farooq F, Masqati NU. Ansari SH, et al. Blood Adv. 2022 Dec 27;6(24):6162-6168. doi: 10.1182/bloodadvances.2022007031. Blood Adv. 2022. PMID: 35477175 Free PMC article.
Trends in 5-, 10-, 20-, and 30-year survival rates of beta-thalassemia patients in Southern Iran, 1995-2016: A retrospective cohort study.
Hassanzadeh J, Mirahmadizadeh A, Karimi M, Veisani Y, Rezaeian S. Hassanzadeh J, et al. J Public Health Res. 2017 Dec 13;6(3):1001. doi: 10.4081/jphr.2017.1001. eCollection 2017 Dec 13. J Public Health Res. 2017. PMID: 29291192 Free PMC article.
A comprehensive review of hydroxyurea for β-haemoglobinopathies: the role revisited during COVID-19 pandemic.
Yasara N, Premawardhena A, Mettananda S. Yasara N, et al. Orphanet J Rare Dis. 2021 Mar 1;16(1):114. doi: 10.1186/s13023-021-01757-w. Orphanet J Rare Dis. 2021. PMID: 33648529 Free PMC article. Review.
Pharmacological Induction of Fetal Hemoglobin in β-Thalassemia and Sickle Cell Disease: An Updated Perspective.
Bou-Fakhredin R, De Franceschi L, Motta I, Cappellini MD, Taher AT. Bou-Fakhredin R, et al. Pharmaceuticals (Basel). 2022 Jun 16;15(6):753. doi: 10.3390/ph15060753. Pharmaceuticals (Basel). 2022. PMID: 35745672 Free PMC article. Review.
Efficacy and safety of hydroxyurea therapy on patients with β-thalassemia: a systematic review and meta-analysis.
Huang T, Jiang H, Tang G, Li J, Huang X, Huang Z, Zhang H. Huang T, et al. Front Med (Lausanne). 2025 Jan 15;11:1480831. doi: 10.3389/fmed.2024.1480831. eCollection 2024. Front Med (Lausanne). 2025. PMID: 39882530 Free PMC article.

See all "Cited by" articles

References

1. Karimi M, Cohan N, De Sanctis V, Mallat NS, Taher A. Guidelines for diagnosis and management of Beta-thalassemia intermedia. Pediatr Haematol Oncol. 2014;31(7):583–96. - PubMed
1. Musallam KM, Taher AT, Rachmilewitz EA. Beta-thalassemia intermedia: a clinical Perspective. Cold Spring Harbor perspectives in Medicine. 2012;2(7):a013482. - PMC - PubMed
1. Musallam KM, Taher AT, Cappellini MD, Sankaran VG. Clinical experience with fetal haemoglobin induction therapy in patients with beta-thalassemia. Blood. 2013;121(12):2199–212. quiz 372. - PubMed
1. Ehsani MA, Hedayati-Asl AA, Bagheri A, Zeinali S, Rashidi A. Hydroxyurea-induced haematological response in transfusion-independent beta-thalassemia intermedia: case series and review of literature. Pediatr Haematol Oncol. 2009;26(8):560–65. - PubMed
1. Italia KY, Jijina FJ, Merchant R, Panjwani S, Nadkarni AH, Sawant PM, et al. Response to hydroxyurea in beta thalassemia major and intermedia: experience in western India. Clinica Chimica Acta; Int J Clin Chem. 2009;407(1-2):10–15. - PubMed

LinkOut - more resources

Full Text Sources
- Europe PubMed Central
- PubMed Central

[1] Karimi M, Cohan N, De Sanctis V, Mallat NS, Taher A. Guidelines for diagnosis and management of Beta-thalassemia intermedia. Pediatr Haematol Oncol. 2014;31(7):583–96. - PubMed

[2] Karimi M, Cohan N, De Sanctis V, Mallat NS, Taher A. Guidelines for diagnosis and management of Beta-thalassemia intermedia. Pediatr Haematol Oncol. 2014;31(7):583–96. - PubMed

[3] Musallam KM, Taher AT, Rachmilewitz EA. Beta-thalassemia intermedia: a clinical Perspective. Cold Spring Harbor perspectives in Medicine. 2012;2(7):a013482. - PMC - PubMed

[4] Musallam KM, Taher AT, Rachmilewitz EA. Beta-thalassemia intermedia: a clinical Perspective. Cold Spring Harbor perspectives in Medicine. 2012;2(7):a013482. - PMC - PubMed

[5] Musallam KM, Taher AT, Cappellini MD, Sankaran VG. Clinical experience with fetal haemoglobin induction therapy in patients with beta-thalassemia. Blood. 2013;121(12):2199–212. quiz 372. - PubMed

[6] Musallam KM, Taher AT, Cappellini MD, Sankaran VG. Clinical experience with fetal haemoglobin induction therapy in patients with beta-thalassemia. Blood. 2013;121(12):2199–212. quiz 372. - PubMed

[7] Ehsani MA, Hedayati-Asl AA, Bagheri A, Zeinali S, Rashidi A. Hydroxyurea-induced haematological response in transfusion-independent beta-thalassemia intermedia: case series and review of literature. Pediatr Haematol Oncol. 2009;26(8):560–65. - PubMed

[8] Ehsani MA, Hedayati-Asl AA, Bagheri A, Zeinali S, Rashidi A. Hydroxyurea-induced haematological response in transfusion-independent beta-thalassemia intermedia: case series and review of literature. Pediatr Haematol Oncol. 2009;26(8):560–65. - PubMed

[9] Italia KY, Jijina FJ, Merchant R, Panjwani S, Nadkarni AH, Sawant PM, et al. Response to hydroxyurea in beta thalassemia major and intermedia: experience in western India. Clinica Chimica Acta; Int J Clin Chem. 2009;407(1-2):10–15. - PubMed

[10] Italia KY, Jijina FJ, Merchant R, Panjwani S, Nadkarni AH, Sawant PM, et al. Response to hydroxyurea in beta thalassemia major and intermedia: experience in western India. Clinica Chimica Acta; Int J Clin Chem. 2009;407(1-2):10–15. - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Clinical and Haematological Effects of Hydroxyurea in β-Thalassemia Intermedia Patients

Affiliations

Clinical and Haematological Effects of Hydroxyurea in β-Thalassemia Intermedia Patients

Authors

Affiliations

Abstract

Similar articles

Cited by

References

LinkOut - more resources

Full Text Sources

Abstract

Similar articles

Cited by

References

Related information

LinkOut - more resources

Full Text Sources