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. 2015:2015:425835.
doi: 10.1155/2015/425835. Epub 2015 Oct 18.

The Role of Systemic Arterial Stiffness in Open-Angle Glaucoma with Diabetes Mellitus

Seong Hee Shim  1 , Chan Yun Kim  2 , Joon Mo Kim  1 , Da Yeong Kim  1 , Yang Jae Kim  1 , Jeong Hun Bae  1 , Ki Chul Sung  3
Affiliations

The Role of Systemic Arterial Stiffness in Open-Angle Glaucoma with Diabetes Mellitus

Seong Hee Shim et al. Biomed Res Int. 2015.

Abstract

Purpose: To investigate the role of systemic arterial stiffness in glaucoma patients with diabetes mellitus (DM).

Design: Retrospective, cross-sectional study.

Participants: DM subjects who underwent brachial-ankle pulse wave velocity (baPWV) were recruited.

Methods: Glaucoma patients (n = 75) and age-matched control subjects (n = 92) were enrolled. Systemic examination including BaPWV and detailed eye examination were performed. The glaucoma group was divided into subgroups of normal tension glaucoma (NTG, n = 55) and primary open-angle glaucoma (POAG) based on an IOP of 21 mmHg. BaPWV was used to stratify the population into 4 groups based on the rate. Stepwise multiple logistic regression analysis by baPWV quartiles was used to compare the glaucoma group with the control group.

Main outcome measures: BaPWV in glaucoma with DM patients.

Results: Faster baPWV was positively associated with glaucoma (odds ratio: 3.74; 95% CI: 1.03-13.56, stepwise multiple logistic regression analysis) in patients with DM. Increasing baPWV was also positively associated with glaucoma (p for trend = 0.036). The NTG subgroup showed similar results to those of the glaucoma group.

Conclusions: In this study, increased arterial stiffness was shown to be associated with glaucoma and may contribute to the pathogenesis of glaucoma in DM patients.

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References

    1. Teikari J. M. Genetic influences in open-angle glaucoma. International Ophthalmology Clinics. 1990;30(3):161–168. doi: 10.1097/00004397-199030030-00003. - DOI - PubMed
    1. Coleman A. L. Glaucoma. The Lancet. 1999;354(9192):1803–1810. doi: 10.1016/s0140-6736(99)04240-3. - DOI - PubMed
    1. Leske M. C. Open-angle glaucoma—an epidemiologic overview. Ophthalmic Epidemiology. 2007;14(4):166–172. doi: 10.1080/09286580701501931. - DOI - PubMed
    1. Kim M., Jeoung J. W., Park K. H., Oh W. H., Choi H. J., Kim D. M. Metabolic syndrome as a risk factor in normal-tension glaucoma. Acta Ophthalmologica. 2014;92(8):e637–e643. doi: 10.1111/aos.12434. - DOI - PubMed
    1. Kim J. M., Kim S. H., Park K. H., Han S. Y., Shim H. S. Investigation of the association between helicobacter pylori infection and normal tension glaucoma. Investigative Ophthalmology and Visual Science. 2011;52(2):665–668. doi: 10.1167/iovs.10-6096. - DOI - PubMed

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