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Review
. 2015;19(4):271-5.
doi: 10.5114/wo.2015.54386. Epub 2015 Sep 28.

Noble metals in oncology

Anna Markowska  1 , Bartosz Kasprzak  2 , Karolina Jaszczyńska-Nowinka  2 , Jolanta Lubin  2 , Janina Markowska  3
Affiliations
Review

Noble metals in oncology

Anna Markowska et al. Contemp Oncol (Pozn). 2015.

Abstract

Worldwide research groups are searching for anticancer compounds, many of them are organometalic complexes having platinum group metals as their active centers. Most commonly used cytostatics from this group are cisplatin, carboplatin and oxaliplatin. Cisplatin was used fot the first time in 1978, from this time many platinum derivatives were created. In this review we present biological properties and probable future clinical use of platinum, gold, silver, iridium and ruthenium derivatives. Gold derivative Auranofin has been studied extensively. Action of silver nanoparticles on different cell lines was analysed. Iridium isotopes are commonly used in brachyterapy. Ruthenium compound new anti-tumour metastasis inhibitor (NAMI-A) is used in managing lung cancer metastases. Electroporation of another ruthenium based compound KP1339 was also studied. Most of described complexes have antiproliferative and proapoptotic properties. Further studies need to be made. Nevertheless noble metal based chemotherapheutics and compounds seem to be an interesting direction of research.

Keywords: gold; noble metals; platinum; silver.

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References

    1. Rosenberg B, van Camp L, Krigas T. Inhibition of cell division in Escherichia coli by electrolysis products from a platinum electrode. Nature. 1965;205:698–99. - PubMed
    1. http://chemocare.com/chemotherapy/drug-info/cisplatin.aspx.
    1. Timerbaev AR, Hartinger CG, Aleksenko SS, Keppler BK. Interactions of antitumor metallodrugs with serum proteins: advances in characterization using modern analytical methodology. Chem Rev. 2006;106:2224–48. - PubMed
    1. Kozelka J, Legendre F, Reeder F, Chottard JC. Kinetic aspects of interactions between DNA and platinum complexes. Coord Chem Rev. 1999;190-192:61–81.
    1. Chaney SG, Campbell SL, Bassett E, Wu Y. Recognition and processing of cisplatin- and oxaliplatin-DNA adducts. Crit Rev Oncol Hematol. 2005;53:3–11. - PubMed

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