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Hepatitis E Virus

Georg Pauli et al. Transfus Med Hemother. 2015 Jul.
No abstract available

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Figures

Fig. 1
Fig. 1
Genome structure and mRNA for the synthesis of structural (ORF2) and non-structural (ORF1 and ORF3) proteins [8,9,10]. The viral genome with a size of about 7.2 kb is methylated (m7G cap) at the 5' end and carries a poly-A sequence (AA) at the 3' end. The 5'- and 3'-end are flanked by non-coding regions (untranslated regions; UTR). ORF1 is translated from the genomic mRNA, encoding a polyprotein with a length of 1,693 amino acids. Computer-assisted analysis of the sequence and comparison to other positive-strand RNA viruses identified four functional domains (MT = methyltransferase; Pro = papain-like cysteine protease; Hel = helicase; Pol = RNA-dependent RNA polymerase). It is not yet completely clear which proteases are involved in the processing of the polyprotein. Two other motifs (X and Y) with unknown function have homologies to other RNA viruses. ORF2 and 3 are translated from a bicistronic subgenomic mRNA with a length of 2.2 kb. ORF2 encodes the capsid protein with a length of 660 amino acids (74 kDa unglycosylated and 88 kDa glycosylated form) and ORF3 codes for a phosphorylated protein with a length of 123 amino acids. The numbers indicate the positions (nucleotide = NT) of the start and end of the corresponding sequences of the viral genome and the vertical bars the predicted hairpin structures of the genome.
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