Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2015 Nov;12(11):2153-9.
doi: 10.1111/jsm.13029. Epub 2015 Nov 12.

Testosterone Concentrations and Cardiovascular Autonomic Neuropathy in Men with Type 1 Diabetes in the Epidemiology of Diabetes Interventions and Complications Study (EDIC)

Catherine Kim  1 , Rodica Pop-Busui  2 , Barbara Braffett  3 , Patricia A Cleary  3 , Ionut Bebu  3 , Hunter Wessells  4 , Trevor Orchard  5 , Aruna V Sarma  6 ; DCCT/E.D.I.C. Research Group
Collaborators, Affiliations
Randomized Controlled Trial

Testosterone Concentrations and Cardiovascular Autonomic Neuropathy in Men with Type 1 Diabetes in the Epidemiology of Diabetes Interventions and Complications Study (EDIC)

Catherine Kim et al. J Sex Med. 2015 Nov.

Abstract

Introduction: Previous studies have reported that lower testosterone concentrations are associated with cardiovascular autonomic neuropathy (CAN), a risk factor for cardiovascular events. However, no studies have examined this relationship in men with type 1 diabetes, who are at high risk for CAN.

Aim: The aim of this study was to examine the associations between testosterone concentrations and measures of CAN in a large, well-characterized cohort of men with type 1 diabetes.

Methods: We conducted an analysis of men in the Diabetes Control and Complications Trial (DCCT), a randomized trial of intensive glucose control, and its observational follow-up the Epidemiology of Diabetes Intervention and Complications (EDIC) Study. Testosterone was measured by liquid chromatography mass spectrometry in stored samples from EDIC follow-up years 10 and 17. Regression models were used to assess the cross-sectional relationships between testosterone and CAN measures.

Main outcome measures: The main CAN measure from EDIC follow-up year 17 was a standardized composite of R-R variation with paced breathing < 15, or R-R variation 15-20 combined with either a Valsalva ratio ≤ 1.5 or a decrease in diastolic blood pressure > 10 mm Hg upon standing. Continuous R-R variation and Valsalva ratio were secondary outcomes.

Results: Lower total and bioavailable testosterone concentrations at follow-up years 10 and 17 were not associated with the presence of CAN at year 17. In analyses using Valsalva ratio as a continuous measure, higher total (P = 0.01) and bioavailable testosterone concentrations (P = 0.005) were associated with a higher (more favorable) Valsalva ratio after adjustment for covariates including age, body mass index, smoking status, hypertension, and glycemia.

Conclusions: Testosterone levels are not associated with CAN among men with type 1 diabetes. Although testosterone is associated with a higher Valsalva ratio, a more favorable indicator, the clinical significance of this association is not known.

Trial registration: ClinicalTrials.gov NCT00360815 NCT00360893.

Keywords: Cardiovascular Autonomic Neuropathy; Cardiovascular Reflex Tests; Testosterone; Type 1 Diabetes.

PubMed Disclaimer

References

    1. Pop-Busui R, Evans G, Gerstein H, et al. Effects of cardiac autonomic dysfunction on mortality risk in the Action to Control Cardiovascular Risk in diabetes (ACCORD) trial. Diabetes Care. 2010;33:1578–84. - PMC - PubMed
    1. Vinik A, Ziegler D. Diabetic cardiovascular autonomic neuropathy. Circulation. 2007;115:387–97. - PubMed
    1. Pop-Busui R, Cleary P, Braffett B, et al. Association between cardiovascular autonomic neuropathy and left ventricular dysfunction: DCCT/EDIC. J Am Coll Cardiol. 2013;61:447–54. - PMC - PubMed
    1. Mogensen U, Jensen T, Kober L, et al. Cardiovascular autonomic neuropathy and subclinical cardiovascular disease in normoalbuminuric type 1 diabetic patients. Diabetes. 2012;61:1822–30. - PMC - PubMed
    1. Akishita M, Hashimoto M, Ohike Y, et al. Low testosterone level as a predictor of cardiovascular events in Japanese men with coronary risk factors. Atherosclerosis. 2009;210:232–6. - PubMed

Publication types

MeSH terms

Associated data