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. 2015 Nov 12;373(20):1895-8.
doi: 10.1056/NEJMp1508811.

The Path to Cancer --Three Strikes and You're Out

Bert Vogelstein  1 , Kenneth W Kinzler
Affiliations

The Path to Cancer --Three Strikes and You're Out

Bert Vogelstein et al. N Engl J Med. .

Abstract

Focusing on driver-gene mutations and the pathways they control has rendered complex cancer-genome landscapes intelligible. In solid tumors of adults, alterations in as few as three driver genes appear to suffice for a cell to evolve into an advanced cancer.

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Comment in

  • N Engl J Med. 2016 Mar 10;374(10):996
  • The Genetic Evolution of Melanoma.
    Lipsker D. Lipsker D. N Engl J Med. 2016 Mar 10;374(10):995. doi: 10.1056/NEJMc1515834. N Engl J Med. 2016. PMID: 26962743 No abstract available.
  • The Genetic Evolution of Melanoma.
    Vogelstein B, Kinzler KW. Vogelstein B, et al. N Engl J Med. 2016 Mar 10;374(10):996. doi: 10.1056/NEJMc1515834. N Engl J Med. 2016. PMID: 26977479 No abstract available.

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