Tyrosine-kinases inhibitors in recurrent platinum-resistant ovarian cancer patients

C Marchetti¹, I Palaia², F De Felice³, A Musella⁴, C Donfracesco⁵, L Vertechy⁶, A Romito⁷, I Piacenti⁸, D Musio⁹, L Muzii¹⁰, V Tombolini¹¹, P Benedetti Panici¹²

Affiliations

¹ Department of Gynecological and Obstetrical Sciences and Urological Sciences, "Sapienza" University of Rome, Rome, Italy. Electronic address: clamarchetti@libero.it.
² Department of Gynecological and Obstetrical Sciences and Urological Sciences, "Sapienza" University of Rome, Rome, Italy. Electronic address: innocenza.palai@uniroma1.it.
³ Department of Radiotherapy, Policlinico Umberto I, "Sapienza" University of Rome, Rome, Italy. Electronic address: fradefelice@hotmail.it.
⁴ Department of Gynecological and Obstetrical Sciences and Urological Sciences, "Sapienza" University of Rome, Rome, Italy. Electronic address: angela.musell@gmail.com.
⁵ Department of Gynecological and Obstetrical Sciences and Urological Sciences, "Sapienza" University of Rome, Rome, Italy. Electronic address: cristina.donfancesco@uniroma1.it.
⁶ Department of Gynecological and Obstetrical Sciences and Urological Sciences, "Sapienza" University of Rome, Rome, Italy. Electronic address: lauravertecy@uniroma1.it.
⁷ Department of Gynecological and Obstetrical Sciences and Urological Sciences, "Sapienza" University of Rome, Rome, Italy. Electronic address: alessia.romto@uniroma1.it.
⁸ Department of Gynecological and Obstetrical Sciences and Urological Sciences, "Sapienza" University of Rome, Rome, Italy. Electronic address: ilarapiacenti@uniroma1.it.
⁹ Department of Radiotherapy, Policlinico Umberto I, "Sapienza" University of Rome, Rome, Italy. Electronic address: danela.musio@uniroma1.it.
¹⁰ Department of Gynecological and Obstetrical Sciences and Urological Sciences, "Sapienza" University of Rome, Rome, Italy. Electronic address: ludovic.muzi@uniroma1.it.
¹¹ Department of Radiotherapy, Policlinico Umberto I, "Sapienza" University of Rome, Rome, Italy. Electronic address: vincenzo.tombolni@uniroma1.it.
¹² Department of Gynecological and Obstetrical Sciences and Urological Sciences, "Sapienza" University of Rome, Rome, Italy. Electronic address: pierluigi.benedettpanici@uniroma1.it.

PMID: 26559739
DOI: 10.1016/j.ctrv.2015.10.011

Review

Tyrosine-kinases inhibitors in recurrent platinum-resistant ovarian cancer patients

C Marchetti et al. Cancer Treat Rev. 2016 Jan.

. 2016 Jan:42:41-6.

doi: 10.1016/j.ctrv.2015.10.011. Epub 2015 Nov 10.

Authors

C Marchetti¹, I Palaia², F De Felice³, A Musella⁴, C Donfracesco⁵, L Vertechy⁶, A Romito⁷, I Piacenti⁸, D Musio⁹, L Muzii¹⁰, V Tombolini¹¹, P Benedetti Panici¹²

Affiliations

¹ Department of Gynecological and Obstetrical Sciences and Urological Sciences, "Sapienza" University of Rome, Rome, Italy. Electronic address: clamarchetti@libero.it.
² Department of Gynecological and Obstetrical Sciences and Urological Sciences, "Sapienza" University of Rome, Rome, Italy. Electronic address: innocenza.palai@uniroma1.it.
³ Department of Radiotherapy, Policlinico Umberto I, "Sapienza" University of Rome, Rome, Italy. Electronic address: fradefelice@hotmail.it.
⁴ Department of Gynecological and Obstetrical Sciences and Urological Sciences, "Sapienza" University of Rome, Rome, Italy. Electronic address: angela.musell@gmail.com.
⁵ Department of Gynecological and Obstetrical Sciences and Urological Sciences, "Sapienza" University of Rome, Rome, Italy. Electronic address: cristina.donfancesco@uniroma1.it.
⁶ Department of Gynecological and Obstetrical Sciences and Urological Sciences, "Sapienza" University of Rome, Rome, Italy. Electronic address: lauravertecy@uniroma1.it.
⁷ Department of Gynecological and Obstetrical Sciences and Urological Sciences, "Sapienza" University of Rome, Rome, Italy. Electronic address: alessia.romto@uniroma1.it.
⁸ Department of Gynecological and Obstetrical Sciences and Urological Sciences, "Sapienza" University of Rome, Rome, Italy. Electronic address: ilarapiacenti@uniroma1.it.
⁹ Department of Radiotherapy, Policlinico Umberto I, "Sapienza" University of Rome, Rome, Italy. Electronic address: danela.musio@uniroma1.it.
¹⁰ Department of Gynecological and Obstetrical Sciences and Urological Sciences, "Sapienza" University of Rome, Rome, Italy. Electronic address: ludovic.muzi@uniroma1.it.
¹¹ Department of Radiotherapy, Policlinico Umberto I, "Sapienza" University of Rome, Rome, Italy. Electronic address: vincenzo.tombolni@uniroma1.it.
¹² Department of Gynecological and Obstetrical Sciences and Urological Sciences, "Sapienza" University of Rome, Rome, Italy. Electronic address: pierluigi.benedettpanici@uniroma1.it.

PMID: 26559739
DOI: 10.1016/j.ctrv.2015.10.011

Abstract

For many decades, ovarian cancer (OC) has been one of the most common gynecological cancer. Despite advances in OC diagnosis and treatment, the risk of recurrence is ever present and approximately 85% of patients will experience relapse. Recurrent OC after first-line therapy is almost always incurable. Multiple novel therapies, including tyrosine-kinases inhibitors (TKI), have shown promising results, but their role needs to be clarified. In this review we describe the rationale and the clinical evidence regarding the use of TKI for the treatment of recurrent platinum-resistant OC patients.

Keywords: Gynecologic; Ovarian cancer; Platinum resistant; Recurrence; Tyrosine-kinases inhibitors.

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Tyrosine-kinases inhibitors in recurrent platinum-resistant ovarian cancer patients

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Tyrosine-kinases inhibitors in recurrent platinum-resistant ovarian cancer patients

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