Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Mar;123(3):277-9.
doi: 10.1007/s00702-015-1478-1. Epub 2015 Nov 11.

Botulinum toxin drugs: brief history and outlook

D Dressler  1
Affiliations
Review

Botulinum toxin drugs: brief history and outlook

D Dressler. J Neural Transm (Vienna). 2016 Mar.

Abstract

The global botulinum toxin (BT) market is currently undergoing rapid changes: this may be the time to review the history and the future of BT drug development. Since the early 1990s Botox(®) and Dysport(®) dominated the international BT market. Later, Myobloc(®)/NeuroBloc(®), a liquid BT type B drug, came out, but failed. Xeomin(®) is the latest major BT drug. It features removal of complexing proteins and improved neurotoxin purity. Several new BT drugs are coming out of Korea, China and Russia. Scientific challenges for BT drug development include modification of BT's duration of action, its transdermal transport and the design of BT hybrid drugs for specific target tissues. The increased competition will change the global BT market fundamentally and a re-organisation according to large indication groups, such as therapeutic and cosmetic applications, might occur.

Keywords: Botulinum toxin; Future perspectives; Global market; History; Therapeutic use.

PubMed Disclaimer

References

    1. Curr Opin Microbiol. 2012 Jun;15(3):325-36 - PubMed
    1. J Pediatr Ophthalmol Strabismus. 1980 Jan-Feb;17(1):21-5 - PubMed
    1. J Neural Transm (Vienna). 2015 Sep;122(9):1279-82 - PubMed
    1. J Neural Transm (Vienna). 2016 May;123(5):527-31 - PubMed
    1. Headache. 2011 Oct;51(9):1358-73 - PubMed

MeSH terms

LinkOut - more resources