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Editorial
. 2015;14(22):3521-2.
doi: 10.1080/15384101.2015.1032636.

Cell aging and kidney repair

Nathan Susnik  1 , Anette Melk  2 , Roland Schmitt  1
Affiliations
Editorial

Cell aging and kidney repair

Nathan Susnik et al. Cell Cycle. 2015.
No abstract available

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Figures

Figure 1.
Figure 1.
Cartoon simplifying the stress induced events in young and old tubular cells. If damage is severe tubular cells die and need to be replenished to restore kidney function. While this repair process is efficient in young cells, cellular senescence, as mirrored by expression of cell cycle inhibitors and possibly by enhanced expression of Cyclin D1, disturbs this process in old cells. Changes in the senescent cell secretome may lead to increased inflammation and fibrosis further hindering repair, worsening disease outcome and leading to chronic kidney disease.
See this image and copyright information in PMC

Comment on

References

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