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Case Reports
. 2015 Nov;35(8):692-5.
doi: 10.1007/s10875-015-0213-x. Epub 2015 Nov 12.

Recurrent Respiratory Infections Revealing CD8α Deficiency

Erwan Dumontet  1   2 , Jennifer Osman  1 , Nathalie Guillemont-Lambert  3 , Guilhem Cros  4   5 , Despina Moshous  4   5   6 , Capucine Picard  7   8   9   10   11   12
Affiliations
Case Reports

Recurrent Respiratory Infections Revealing CD8α Deficiency

Erwan Dumontet et al. J Clin Immunol. 2015 Nov.

Abstract

CD8A encodes the CD8α chain of the dimeric CD8 protein, a critical coreceptor of cytotoxic T cells. We report here the comprehensive immunological evaluation of a child with a CD8A missense mutation, providing evidence that CD8 deficiency increases susceptibility to recurrent respiratory infections without interfering with the TCR-mediated proliferation of T cells. These observations expand the known phenotypes associated with CD8 deficiency.

Keywords: CD8; CD8A; CID combined immune deficiency; TCR signaling; immunophenotyping.

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References

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