Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Mar 15;213(6):930-3.
doi: 10.1093/infdis/jiv532. Epub 2015 Nov 12.

Stability of a Vesicular Stomatitis Virus-Vectored Ebola Vaccine

Marianne Arnemo  1 , Sara Sofie Viksmoen Watle  2 , Kristin Merete Schoultz  2 , Kirsti Vainio  2 , Gunnstein Norheim  2 , Vasee Moorthy  3 , Patricia Fast  4 , John-Arne Røttingen  5 , Tor Gjøen  1
Affiliations

Stability of a Vesicular Stomatitis Virus-Vectored Ebola Vaccine

Marianne Arnemo et al. J Infect Dis. .

Abstract

The live attenuated vesicular stomatitis virus-vectored Ebola vaccine rVSV-ZEBOV is currently undergoing clinical trials in West Africa. The vaccine is to be stored at -70°C or less. Since maintaining the cold chain is challenging in rural areas, the rVSV-ZEBOV vaccine's short-term and long-term stability at different temperatures was examined. Different dilutions were tested since the optimal vaccine dosage had not yet been determined at the start of this experiment. The results demonstrate that the original vaccine formulation was stable for 1 week at 4°C and for 24 hours at 25°C. The stability of the vaccine was compromised by both high temperatures and dilution.

Keywords: Ebola; VSV; stability; vaccine; virus.

PubMed Disclaimer

Publication types