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Review
. 2015;11(12):2379-80.
doi: 10.1080/15548627.2015.1108509.

Mitophagy in mitosis: More than a myth

Lorena Esteban-Martínez  1   2 , Elena Doménech  1 , Patricia Boya  2 , María Salazar-Roa  1 , Marcos Malumbres  1
Affiliations
Review

Mitophagy in mitosis: More than a myth

Lorena Esteban-Martínez et al. Autophagy. 2015.
No abstract available

Keywords: cancer therapy; cell cycle; glycolysis; microtubule poisons; mitophagy; mitosis.

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Figures

Figure 1.
Figure 1.
Mitotic arrest, such as the one imposed by microtubule poisons, induces a series of cellular changes to prolong cell survival. The induction of autophagy in the absence of organelle biogenesis results in mitophagy (green dots in the upper panel) and the depletion of functional mitochondria, leading to the presence of reactive oxygen species (ROS) and low ATP levels. This stimulates the activity of AMPK resulting in PFKFB3 phosphorylation and the induction of glycolysis, in order to fulfill the high energetic requirements of mitotic cells. The balance between ROS and ATP levels determines whether cells eventually die using caspase-dependent or -independent pathways before cells can escape from the mitotic arrest. (Art designs by mcasasengel@gmail.com.)
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  • doi: 10.1038/ncb3231

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