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Review
. 2016;16(1):71-81.
doi: 10.1586/14737140.2016.1121109. Epub 2015 Dec 7.

Current status and future perspectives of fluorescence-guided surgery for cancer

Jonathan C DeLong  1 , Robert M Hoffman  1   2 , Michael Bouvet  1
Affiliations
Review

Current status and future perspectives of fluorescence-guided surgery for cancer

Jonathan C DeLong et al. Expert Rev Anticancer Ther. 2016.

Abstract

Curative cancer surgery is dependent on the removal of all primary tumor and metastatic cancer cells. Preoperative imaging, intraoperative inspection and palpation, as well as pathological margin confirmation aid the surgeon, but these methods are lacking in sensitivity and can be highly subjective. Techniques in fluorescence-guided surgery (FGS) are emerging that selectively illuminate cancer cells, enhancing the distinction between tumors and surrounding tissues with the potential for single-cell sensitivity. FGS enhances tumor detection, surgical navigation, margin confirmation, and in some cases can be combined with therapeutic techniques to eliminate microscopic disease. In this review, we describe the preclinical developments and currently-used techniques for FGS.

Keywords: Fluorescence-guided surgery (FGS); fluorescent proteins; fluorophore; photoimmunotherapy; theranostics.

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References

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