Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2015 Nov 15;192(10):1260-1.
doi: 10.1164/rccm.201507-1321LE.

Comprehensive Validation of the FAIM3:PLAC8 Ratio in Time-matched Public Gene Expression Data

Timothy E Sweeney  1 , Purvesh Khatri  1
Affiliations
Comment

Comprehensive Validation of the FAIM3:PLAC8 Ratio in Time-matched Public Gene Expression Data

Timothy E Sweeney et al. Am J Respir Crit Care Med. .
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Receiver operating characteristic curves showing the diagnostic power of sterile SIRS/trauma patients versus patients with sepsis in multiple public gene expression datasets. (A) Datasets comparing patients at intensive care unit admission. (B) Subcohorts of time-matched trauma patients, split out by days since initial injury. Buffy coat and neutrophil data were from separate patient cohorts. AUC = area under the receiver operating characteristic curve; CAP = community-acquired pneumonia; FAIM3 = Fas apoptotic inhibitory molecule 3; ICU = intensive care unit; MICU = medical ICU; PICU = pediatric ICU; PLAC8 = placenta-specific 8; SIRS = systemic inflammatory response syndrome.
See this image and copyright information in PMC

Comment in

Comment on

References

    1. Scicluna BP, Klein Klouwenberg PM, van Vught LA, Wiewel MA, Ong DS, Zwinderman AH, Franitza M, Toliat MR, Nürnberg P, Hoogendijk AJ, et al. A molecular biomarker to diagnose community-acquired pneumonia on intensive care unit admission. Am J Respir Crit Care Med. 2015;192:826–835. - PubMed
    1. Ferrer R, Martin-Loeches I, Phillips G, Osborn TM, Townsend S, Dellinger RP, Artigas A, Schorr C, Levy MM. Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: results from a guideline-based performance improvement program. Crit Care Med. 2014;42:1749–1755. - PubMed
    1. Sweeney TE, Shidham A, Wong HR, Khatri P. A comprehensive time-course-based multicohort analysis of sepsis and sterile inflammation reveals a robust diagnostic gene set. Sci Transl Med. 2015;7:287ra71. - PMC - PubMed
    1. Xiao W, Mindrinos MN, Seok J, Cuschieri J, Cuenca AG, Gao H, Hayden DL, Hennessy L, Moore EE, Minei JP, et al. Inflammation and Host Response to Injury Large-Scale Collaborative Research Program. A genomic storm in critically injured humans. J Exp Med. 2011;208:2581–2590. - PMC - PubMed
    1. Parnell GP, McLean AS, Booth DR, Armstrong NJ, Nalos M, Huang SJ, Manak J, Tang W, Tam OY, Chan S, et al. A distinct influenza infection signature in the blood transcriptome of patients with severe community-acquired pneumonia. Crit Care. 2012;16:R157. - PMC - PubMed