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Review
. 2015 Dec:15:112-8.
doi: 10.1016/j.coviro.2015.10.003. Epub 2015 Dec 6.

Dissecting vectorial capacity for mosquito-borne viruses

Laura D Kramer  1 , Alexander T Ciota  2
Affiliations
Review

Dissecting vectorial capacity for mosquito-borne viruses

Laura D Kramer et al. Curr Opin Virol. 2015 Dec.

Abstract

The inter-relationship between mosquitoes and the viruses they transmit is complex. While previously understood barriers to infection and transmission remain valid, additional factors have been uncovered that suggest an 'arms race' between mosquito and virus. These include the mosquito microbiota and interplay between mosquito and viral genetics. Following an infectious blood meal, the mosquito mounts an immune and transcriptional response, leading to altered expression of multiple genes. These complex interactions, specific to vector and virus genotypes, combine with external influences, particularly temperature, to determine vector competence. The mosquito's response to the infecting agent may have consequences in terms of longevity, feeding behavior and/or fecundity. These factors, together with population density and the frequency of host contact determine vectorial capacity.

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Figures

Figure
Figure
Factors affecting vectorial capacity of a mosquito vector
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