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. 2015 Dec 22;27(48):7945-50.
doi: 10.1002/adma.201503935. Epub 2015 Nov 17.

Multifunctional Silica Nanoparticles for Covalent Immobilization of Highly Sensitive Proteins

Xu-Dong Wang  1 , Kersten S Rabe  1 , Ishtiaq Ahmed  1 , Christof M Niemeyer  1
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Multifunctional Silica Nanoparticles for Covalent Immobilization of Highly Sensitive Proteins

Xu-Dong Wang et al. Adv Mater. .

Abstract

A convenient reverse micellar one-pot reaction yields multifunctional silica nanoparticles, which can be tailored to effectively suppress non-specific adsorption and, at the same time, enable efficient specific covalent immobilization of proteins. Using two highly sensitive proteins, it is demonstrated that the new particles provide a suitable microenvironment to maintain the protein's activity.

Keywords: biomolecules; immobilization; proteins; silica nanoparticles; surface chemistry.

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