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. 1977 Apr;35(4):479-83.
doi: 10.1038/bjc.1977.71.

Early central nervous system involvement in adults with acute non-myelogenous leukaemia

T A Lister, J M Whitehouse, M E Beard, A Paxton, R L Brearley, L Brown, P F Wrigley, D Crowther
Free PMC article

Early central nervous system involvement in adults with acute non-myelogenous leukaemia

T A Lister et al. Br J Cancer. 1977 Apr.
Free PMC article

Abstract

Of 47 consecutive patients aged 15-60 years with acute non-myelogenous leukaemia (ANML) (40 acute lymphoblastic leukaemia (ALL); 5 acute Burkitt-like leukaemia (ABLL), 2 acute undifferentiated leukaemia (AUL) treated with a standard chemotherapy protocol (OPAL), 31 achieved complete remission (28/40(70%) of patients with ALL). CNS leukaemia occurred in 4/16 non-remitters, and in 6 patients who achieved complete remission (CR). CNS leukaemia occurred in all 5 patients with acute Burkitt-like leukaemia. 4/28 patients with ALL achieving CR had evidence of CSF involvement on cytocentrifuge examination shortly after CR. The apparent risk of early CNS disease suggests that prophylactic CNS therapy should be given early in the treatment of acute non-myelogenous leukaemia.

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