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Review
. 2015 Sep;35(5):439-43.
doi: 10.1016/j.semnephrol.2015.08.005.

The Role of Anti-DNA Antibodies in the Development of Lupus Nephritis: A Complementary, or Alternative, Viewpoint?

Beatrice Goilav  1 , Chaim Putterman  2
Affiliations
Review

The Role of Anti-DNA Antibodies in the Development of Lupus Nephritis: A Complementary, or Alternative, Viewpoint?

Beatrice Goilav et al. Semin Nephrol. 2015 Sep.

Abstract

Kidney disease, or lupus nephritis, is the organ involvement that is most closely associated with specific autoantibodies in patients with SLE. The concept of anti-DNA antibodies being instrumental in the pathogenesis of lupus nephritis emerged ~50 years ago, and has been a topic of debate ever since. This article focuses on the description of the renal sub-cellular targets of nephritogenic autoantibodies and offers a counter-point opinion to the article by Pedersen et al. In addition, we provide an overview of some of the mechanisms by which anti-DNA antibodies bind to their renal targets and the pathogenic relevance to clinical nephritis.

Keywords: Lupus nephritis; anti-DNA antibodies; cross-reactivity; nephritogenic antibodies.

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