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Comment
. 2015 Nov 16;212(12):1990.
doi: 10.1084/jem.21212insight3.

Effective effector generation of CD8+ T cells and NK cells: A need for T-bet and ZEB-too

Sara E Hamilton  1 , Stephen C Jameson  1
Affiliations
Comment

Effective effector generation of CD8+ T cells and NK cells: A need for T-bet and ZEB-too

Sara E Hamilton et al. J Exp Med. .
No abstract available

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Figures

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Insight from Sara Hamilton (left) and Stephen Jameson (right)
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It takes Zeb2 to tango: Cooperation between T-bet and Zeb2 is essential for CD8+ T cell effector differentiation and NK cell development. Although increasing T-bet expression alone can mediate some of the necessary gene expression changes, coordination with Zeb2 (which is itself under T-bet transcriptional control) is required for full commitment and expansion of terminally differentiated CD8+ T cells and mature NK cells.
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References

    1. Dominguez, C.X., et al. 2015. J. Exp. Med. 10.1084/jem.20150186 - DOI
    1. Omilusik, K.D., et al. 2015. J. Exp. Med. 10.1084/jem.20150194 - DOI
    1. van Helden, M.J., et al. 2015. J. Exp. Med. 10.1084/jem.20150809 - DOI

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