Polycyclic aromatic hydrocarbons: determinants of residential carpet dust levels and risk of non-Hodgkin lymphoma

Affiliations

¹ Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), 9609 Medical Center Dr, Room 6E138 MSC 9771, Bethesda, MD, 20892, USA.
² Yale School of Public Health, New Haven, CT, USA.
³ Department of Environmental and Occupational Health, Drexel University School of Public Health, Philadelphia, PA, USA.
⁴ Division of Epidemiology, Mayo Clinic, Rochester, MN, USA.
⁵ University of Southern California, Los Angeles, CA, USA.
⁶ Department of Family Medicine and Public Health Sciences, Wayne State University, Detroit, MI, USA.
⁷ Westat Inc., Rockville, MD, USA.
⁸ Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
⁹ Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), 9609 Medical Center Dr, Room 6E138 MSC 9771, Bethesda, MD, 20892, USA. wardm@mail.nih.gov.

PMID: 26573845
PMCID: PMC5358542
DOI: 10.1007/s10552-015-0660-y

Polycyclic aromatic hydrocarbons: determinants of residential carpet dust levels and risk of non-Hodgkin lymphoma

Curt T DellaValle et al. Cancer Causes Control. 2016 Jan.

. 2016 Jan;27(1):1-13.

doi: 10.1007/s10552-015-0660-y. Epub 2015 Nov 16.

Authors

Affiliations

¹ Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), 9609 Medical Center Dr, Room 6E138 MSC 9771, Bethesda, MD, 20892, USA.
² Yale School of Public Health, New Haven, CT, USA.
³ Department of Environmental and Occupational Health, Drexel University School of Public Health, Philadelphia, PA, USA.
⁴ Division of Epidemiology, Mayo Clinic, Rochester, MN, USA.
⁵ University of Southern California, Los Angeles, CA, USA.
⁶ Department of Family Medicine and Public Health Sciences, Wayne State University, Detroit, MI, USA.
⁷ Westat Inc., Rockville, MD, USA.
⁸ Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.
⁹ Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), 9609 Medical Center Dr, Room 6E138 MSC 9771, Bethesda, MD, 20892, USA. wardm@mail.nih.gov.

PMID: 26573845
PMCID: PMC5358542
DOI: 10.1007/s10552-015-0660-y

Abstract

Purpose: To investigate the risk of non-Hodgkin lymphoma (NHL) associated with residential carpet dust measurements of polycyclic aromatic hydrocarbons (PAHs).

Methods: We evaluated the relationship between residential carpet dust PAH concentrations (benz(a)anthracene, benzo(a)pyrene, benzo(b)fluoranthene, benzo(k)fluoranthene, chrysene, dibenz(a,h)anthracene, and indeno(1,2,3-c,d)pyrene, and their sum) and risk of NHL (676 cases, 511 controls) in the National Cancer Institute Surveillance Epidemiology and End Results multicenter case-control study. As a secondary aim, we investigated determinants of dust PAH concentrations. We computed odds ratios (OR) and 95 % confidence interval (CI) for associations between NHL and concentrations of individual and summed PAHs using unconditional logistic regression, adjusting for age, gender, and study center. Determinants of natural log-transformed PAHs were investigated using multivariate least-squares regression.

Results: We observed some elevated risks for NHL overall and B cell lymphoma subtypes in association with quartiles or tertiles of PAH concentrations, but without a monotonic trend, and there was no association comparing the highest quartile or tertile to the lowest. In contrast, risk of T cell lymphoma was significantly increased among participants with the highest tertile of summed PAHs (OR = 3.04; 95 % CI, 1.09-8.47) and benzo(k)fluoranthene (OR = 3.20; 95 % CI, 1.13-9.11) compared with the lowest tertile. Predictors of PAH dust concentrations in homes included ambient air PAH concentrations and the proportion of developed land within 2 km of a residence. Older age, more years of education, and white race were also predictive of higher levels in homes.

Conclusion: Our results suggest a potential link between PAH exposure and risk of T cell lymphoma and demonstrate the importance of analyzing risk by NHL histologic type.

Keywords: Case–control study; Dust; Non-Hodgkin lymphoma; Polycyclic aromatic hydrocarbons; T cell lymphoma.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest The authors declare that they have no conflict of interest.

References

1. U.S. Department of Health and Human Services, Agency for Toxic Substances and Disease. Toxicological profile for polycyclic aromatic hydrocarbons. 1995 Retrieved from http://www.atsdr.cdc.gov/toxprofiles/tp.asp?id=122&tid=25. - PubMed
1. IARC. Polynuclear aromatic compounds. World Health Organization; Lyon: 1983.
1. IARC. Some non-heterocyclic polycyclic aromatic hydrocarbons and some related exposures. World Health Organization; Lyon: 2007. - PMC - PubMed
1. Boffetta P, Jourenkova N, Gustavsson P. Cancer risk from occupational and environmental exposure to polycyclic aromatic hydrocarbons. Cancer Causes Control. 1997;8:444–472. - PubMed
1. Yu Z, Loehr CV, Fischer KA, et al. In utero exposure of mice to dibenzo a, l pyrene produces lymphoma in the offspring: role of the aryl hydrocarbon receptor. Cancer Res. 2006;66:755–762. - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Polycyclic aromatic hydrocarbons: determinants of residential carpet dust levels and risk of non-Hodgkin lymphoma

Affiliations

Polycyclic aromatic hydrocarbons: determinants of residential carpet dust levels and risk of non-Hodgkin lymphoma

Authors

Affiliations

Abstract

Conflict of interest statement

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Research Materials