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Review
. 2016 Jan;25(1):16-21.
doi: 10.1097/MNH.0000000000000189.

Aldosterone in vascular and metabolic dysfunction

James M Luther  1
Affiliations
Review

Aldosterone in vascular and metabolic dysfunction

James M Luther. Curr Opin Nephrol Hypertens. 2016 Jan.

Abstract

Purpose of review: This review will highlight recent developments in mineralocorticoid receptor research which impact aldosterone-associated vascular and cardiometabolic dysfunction.

Recent findings: The mineralocorticoid receptor is also expressed in vascular smooth muscle and vascular endothelium, and contributes to vascular function and remodeling. Adipocyte-derived leptin stimulates aldosterone secretion, which may explain the observed link between obesity and hyperaldosteronism. Adipocyte mineralocorticoid receptor overexpression produces systemic changes consistent with metabolic syndrome. Ongoing studies with novel nonsteroidal mineralocorticoid receptor antagonists may provide a novel treatment for diabetic nephropathy and heart failure in patients with chronic kidney disease, with reduced risk of hyperkalemia.

Summary: Ongoing research continues to demonstrate novel roles of the vascular and adipocyte mineralocorticoid receptor function, which may explain the beneficial metabolic and vascular benefits of mineralocorticoid receptor antagonists.

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Conflict of interest statement

CONFLICTS OF INTEREST: No conflict of interest declared

Figures

Figure 1
Figure 1
Interaction between adipocytes and aldosterone production in zona glomerulosa cells. Ang, Angiotensin; AT1, angiotensin II type I receptor; LR, leptin receptor; MR, mineralocorticoid receptor; PTGDS, prostaglandin D synthase; ZG, zona glomerulosa.
See this image and copyright information in PMC

References

    1. Goodfriend TL, Egan BM, Kelley DE. Plasma aldosterone, plasma lipoproteins, obesity and insulin resistance in humans. Prostaglandins Leukot Essent Fatty Acids. 1999;60:401–405. - PubMed
    1. Ehrhart-Bornstein M, Lamounier-Zepter V, Schraven A, et al. Human adipocytes secrete mineralocorticoid-releasing factors. Proc Natl Acad Sci USA. 2003;100:14211–14216. - PMC - PubMed
    1. Allison MA, Jenny NS, McClelland RL, et al. The associations of adipokines with selected markers of the renin-angiotensinogen-aldosterone system: The multi-ethnic study of atherosclerosis. J Hum Hypertens. 2015;29:127–133. - PMC - PubMed
    1. Huby AC, Antonova G, Groenendyk J, et al. The adipocyte-derived hormone leptin is a direct regulator of aldosterone secretion, which promotes endothelial dysfunction and cardiac fibrosis. Circulation. 2015 doi: 10.1161/CIRCULATIONAHA.115.018226. Epub ahead of print. - DOI - PubMed
    1. Ingelsson E, Pencina MJ, Tofler GH, et al. Multimarker approach to evaluate the incidence of the metabolic syndrome and longitudinal changes in metabolic risk factors: The framingham offspring study. Circulation. 2007;116:984–992. - PubMed

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