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Review
. 2015:2015:732438.
doi: 10.1155/2015/732438. Epub 2015 Oct 21.

Potential Use of Natural Killer Cell Transfer Therapy in the Perioperative Period to Improve Oncologic Outcomes

Juan P Cata  1 , Claudius Conrad  2 , Katy Rezvani  3
Affiliations
Review

Potential Use of Natural Killer Cell Transfer Therapy in the Perioperative Period to Improve Oncologic Outcomes

Juan P Cata et al. Scientifica (Cairo). 2015.

Abstract

Immune suppression after oncologic surgery is a common phenomenon. Several studies have demonstrated that it is associated with poor survival owing to cancer progression. Immunotherapy, especially NK cell transfer therapy, is an attractive alternative because current methodologies to isolate, generate, and expand NK cells have shown good safety profiles in current active investigations. We believe that the use of NK cell transfer therapy in the context of postoperative minimal residual disease deserves significant investigation.

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Figures

Figure 1
Figure 1
Commonly observed biphasic response in natural killer (NK) cell count and activity during and after surgery.
Figure 2
Figure 2
Postulated mechanisms behind the observed quantitative (a) and qualitative (b) changes in natural killer (NK) cells during and after surgery.
Figure 3
Figure 3
Expected changes in natural killer (NK) cell function and count after the preoperative or “preventive” infusion of expanded allogeneic or autologous NK cells (NKTT).
See this image and copyright information in PMC

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