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. 2015 Nov 10:4:688.
doi: 10.1186/s40064-015-1449-x. eCollection 2015.

Prevalence, risk factors, and prognosis of peritoneal metastasis from breast cancer

Serena Bertozzi #  1   2 , Ambrogio P Londero #  3 , Carla Cedolini #  1 , Alessandro Uzzau  1 , Luca Seriau  1 , Sergio Bernardi  4 , Stefano Bacchetti  1 , Enrico Maria Pasqual  1 , Andrea Risaliti  1
Affiliations

Prevalence, risk factors, and prognosis of peritoneal metastasis from breast cancer

Serena Bertozzi et al. Springerplus. .

Abstract

Peritoneal metastasis from breast cancer is a serious and deadly condition only limited considered in the literature. Our aim was to study prevalence, risk factors, and prognosis of breast cancer peritoneal metastasis. We retrospectively analyzed 3096 women with a diagnosis of invasive breast cancer. We took into consideration presence and localization of breast cancer distant metastasis as well as the possible risk factors and survival from the diagnosis of the breast cancer metastasis. The prevalence of breast cancer peritoneal metastases was 0.7 % (22/3096), representing the 7.6 % (22/289) of women affected by distant metastases. Moreover, independent risk factors for breast cancer peritoneal metastases resulted high grading, lobular invasive histology, and advanced T and N stage at diagnosis. Overall survival after metastasis diagnosis was shorter in women affected by peritoneal metastases or brain metastases in comparison to other metastatic women. Breast cancer peritoneal metastases were uncommon but not rare events with a poor prognosis after standard treatments.

Keywords: Breast cancer; Distant metastasis, peritoneal metastasis; Overall survival; Peritoneal carcinomatosis.

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Figures

Fig. 1
Fig. 1
a Cumulative distant metastases appearance during the follow-up and TNM stage at diagnosis, b 2 years overall survival after the appearance of distant metastases. The difference between women affected by pertitoneal carcinomatosis (M1—peritoneum) and other metastases (excluding brain) was statistically significant (p < 0.05) as well as the difference between women affected by brain metastases and women affected by other metastases (p < 0.05). c Two years overall survival after the appearance of peritoneal carcinomatosis (M1—peritoneum) in our population and in cases referred by the literature to be treated by HIPEC procedure (Cardi et al. ; Garofalo et al. 2006). We found a significant longer survival in patients treated by HIPEC procedure (p < 0.05)
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