Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2015:2015:409174.
doi: 10.1155/2015/409174. Epub 2015 Oct 21.

Effects of Whole-Body Cryotherapy in Comparison with Other Physical Modalities Used with Kinesitherapy in Rheumatoid Arthritis

Małgorzata Gizińska  1 , Radosław Rutkowski  1 , Wojciech Romanowski  2 , Jacek Lewandowski  3 , Anna Straburzyńska-Lupa  4
Affiliations
Clinical Trial

Effects of Whole-Body Cryotherapy in Comparison with Other Physical Modalities Used with Kinesitherapy in Rheumatoid Arthritis

Małgorzata Gizińska et al. Biomed Res Int. 2015.

Abstract

Whole-body cryotherapy (WBC) has been frequently used to supplement the rehabilitation of patients with rheumatoid arthritis (RA). The aim of this study was to compare the effect of WBC and traditional rehabilitation (TR) on clinical parameters and systemic levels of IL-6, TNF-α in patients with RA. The study group comprised 25 patients who were subjected to WBC (-110 °C) and 19 patients who underwent a traditional rehabilitation program. Some clinical variables and levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were used to assess the outcomes. After therapy both groups exhibited similar improvement in pain, disease activity, fatigue, time of walking, and the number of steps over a distance of 50 m. Only significantly better results were observed in HAQ in TR group (p < 0.05). However, similar significant reduction in IL-6 and TNF-α level was observed. The results showed positive effects of a 2-week rehabilitation program for patients with RA regardless of the kind of the applied physical procedure.

PubMed Disclaimer

References

    1. Aletaha D., Neogi T., Silman A. J., et al. 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis & Rheumatism. 2010;62(9):2569–2581. doi: 10.1002/art.27584. - DOI - PubMed
    1. Choy E. Understanding the dynamics: pathways involved in the pathogenesis of rheumatoid arthritis. Rheumatology. 2012;51(5):3–11. doi: 10.1093/rheumatology/kes113.kes113 - DOI - PubMed
    1. Hashizume M., Mihara M. The roles of interleukin-6 in the pathogenesis of rheumatoid arthritis. Arthritis. 2011;2011:8. doi: 10.1155/2011/765624.765624 - DOI - PMC - PubMed
    1. Banfi G., Melegati G., Barassi A., et al. Effects of whole-body cryotherapy on serum mediators of inflammation and serum muscle enzymes in athletes. Journal of Thermal Biology. 2009;34(2):55–59. doi: 10.1016/j.jtherbio.2008.10.003. - DOI
    1. Badolato R., Oppenheim J. J. Role of cytokines, acute-phase proteins, and chemokines in the progression of rheumatoid arthritis. Seminars in Arthritis and Rheumatism. 1996;26(2):526–538. doi: 10.1016/s0049-0172(96)80041-2. - DOI - PubMed

LinkOut - more resources