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Review
. 2015:2015:468627.
doi: 10.1155/2015/468627. Epub 2015 Oct 4.

The Protective Effect of Transcription Factor 7-Like 2 Risk Allele rs7903146 against Elevated Fasting Plasma Triglyceride in Type 2 Diabetes: A Meta-Analysis

Shuxia Wang  1 , Kangxing Song  2 , Roshni Srivastava  3 , Mohsen Fathzadeh  3 , Na Li  3 , Arya Mani  4
Affiliations
Review

The Protective Effect of Transcription Factor 7-Like 2 Risk Allele rs7903146 against Elevated Fasting Plasma Triglyceride in Type 2 Diabetes: A Meta-Analysis

Shuxia Wang et al. J Diabetes Res. 2015.

Abstract

Background: The results from published studies regarding association of transcription factor 7-like 2 (TCF7L2) variant rs7903146 with dyslipidemia have been conflicting and inconclusive.

Methods: We carried out a meta-analysis that aimed to investigate the association of the rs7903146 variant with plasma lipid levels using electronic database and published studies. Data was extracted by a standard algorithm. Dominant, recessive, homozygote, and heterozygote comparison models were utilized.

Results: 24 studies incorporating 52,785 subjects were included in this meta-analysis. Overall, the minor allele (T) was associated with lower risk for hypertriglyceridemia in subjects with type 2 diabetes (dominant model: SMD = -0.04, 95% CI (-0.08, 0.00), P = 0.048, P heterogeneity = 0.47; recessive model: SMD = -0.10, 95% CI (-0.18, -0.02), P = 0.01, P heterogeneity = 0.56). No association was found between minor (T) allele and plasma TC, LDL-c, or HDL-c levels in subjects with type 2 diabetes or metabolic syndrome (MetS) and no association was found between minor (T) allele and plasma TG levels in nondiabetic subjects.

Conclusions: Our meta-analysis indicated the association between TCF7L2 rs7903146 polymorphism and low plasma triglyceride (TG) level in subjects with type 2 diabetes. No association was found between rs7903146 variant and plasma lipids in nondiabetic subjects.

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Figures

Figure 1
Figure 1
Flowchart outlining the process of search criteria and study selection.
Figure 2
Figure 2
Forest plot of the TGCF7L2 rs7903146 polymorphism and triglyceride association: (a) dominant model, TT + TC versus CC, (b) recessive model, TT versus TC + CC, (c) homozygous model, TT versus CC, and (d) heterozygous model, TC versus CC.
Figure 3
Figure 3
Funnel plot of TGCF7L2 rs7903146 polymorphism and triglyceride association in dominant model (a), recessive model (b), homozygous recessive model (c), and heterozygous model (d).
See this image and copyright information in PMC

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