Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Aug;63(8):674-8.
doi: 10.4103/0301-4738.169792.

Metastatic adenocarcinoma of the cervix presenting as a choroidal mass: A case report and review of literature of cervical metastases to the eye

Akshay Gopinathan Nair  1 , Haresh T Asnani, Vinod C Mehta, Siddharth V Mehta, Rima S Pathak
Affiliations
Review

Metastatic adenocarcinoma of the cervix presenting as a choroidal mass: A case report and review of literature of cervical metastases to the eye

Akshay Gopinathan Nair et al. Indian J Ophthalmol. 2015 Aug.

Abstract

Cervical cancer is the most common cancer among females in India. Cervical cancer usually spreads by local extension and through the lymphatic drainage to the lymph nodes. Hematogenous spread, the mechanism responsible for distant metastases, is rarely seen in cervical malignancies. In this communication, we report a case of a 45-year-old woman who presented with unilateral decrease in vision of 3 months duration. She was found to have a serous retinal detachment with underlying diffuse, subretinal yellowish-cream colored infiltrates in the right eye, suspicious of choroidal metastases. Systemic evaluation showed disseminated systemic metastases arising from a primary adenocarcinoma of the cervix. In this communication, we review all the documented cases of metastases to the eye and adnexa arising from cervical cancer and their clinical characteristics. Unilateral choroidal metastasis arising from an adenocarcinoma of the cervix is extremely rare with only one previous documented case. Although uncommon, choroidal metastasis may be the presenting feature of primary cervical malignancy. Furthermore, cervical malignancy must be ruled out in women who present with orbital or choroidal metastases arising from unknown primary.

PubMed Disclaimer

Figures

Figure 1
Figure 1
(a) Fundus photograph of the right eye showing serous retinal detachment with underlying choroidal, diffuse, yellowish-cream colored infiltrates. (b) Composite image of the fluorescein angiogram in the late phase demonstrating hyperfluorescence along with pin-point discrete leakages from the choroidal masses
Figure 2
Figure 2
Axial (a) and coronal (b) slices of high-resolution computed tomography images of the chest demonstrate multiple bilateral randomly distributed metastatic nodules of varying sizes. (c) A positron emission tomography image showing hyper metabolic spots in the lungs, right supraclavicular lymph node and brain suggesting disseminated metastases
See this image and copyright information in PMC

References

    1. Gosslee JM, Misra RP, Langford MP, Vekovius B, Byrd WA, Flynn SB. Orbital metastasis of keratinizing squamous cell cervical carcinoma with giant cells. A case report. Int Ophthalmol. 2009;29:39–44. - PubMed
    1. Kaarthigeyan K. Cervical cancer in India and HPV vaccination. Indian J Med Paediatr Oncol. 2012;33:7–12. - PMC - PubMed
    1. Setoodeh R, Hakam A, Shan Y. Cerebral metastasis of cervical cancer, report of two cases and review of the literature. Int J Clin Exp Pathol. 2012;5:710–4. - PMC - PubMed
    1. Hertzanu Y, Vellet AD, Fain BA, Ferreira MM, Ninin DT. Eye metastases in carcinoma of the cervix. A case report. S Afr Med J. 1987;71:53–4. - PubMed
    1. Kurosawa A, Sawaguchi S. Iris metastasis from squamous cell carcinoma of the uterine cervix. Case report. Arch Ophthalmol. 1987;105:618. - PubMed