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Editorial
. 2015 Nov 3;6(34):35133-4.
doi: 10.18632/oncotarget.6032.

Longistatin in tick-saliva targets RAGE

Anisuzzaman  1   2 , M Abdul Alim  1   2 , Naotoshi Tsuji  2   3
Affiliations
Editorial

Longistatin in tick-saliva targets RAGE

Anisuzzaman et al. Oncotarget. .
No abstract available

Keywords: longistatin; receptor for advanced glycation end products (RAGE); tick-saliva.

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Figures

Figure 1
Figure 1. Schematic presentation of roles of longistatin in RAGE-mediated inflammations
Ticks cause extensive tissue damage. Dead or devitalized tissues release DAMPs or alarmins, which are responsible for eliciting inflammation, mainly through RAGE engagement, but longistatin prevents interaction of the receptor with the DAMPs. Longistatin effectively suppresses adhesion molecules and relevant cytokine production preventing nuclear translocation of NF-kB.
See this image and copyright information in PMC

References

    1. Anisuzzaman, et al. PLoS Pathog. 2011;7:e1001312. - PMC - PubMed
    1. Anisuzzaman, et al. J Clin Invest. 2014;124:4429–4444. - PMC - PubMed
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    1. Islam MK, et al. PLoS Pathog. 2009;5:e1000497. - PMC - PubMed
    1. Anisuzzaman, et al. Int J Parasitol. 2010;40:721–729. - PubMed

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