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Randomized Controlled Trial
. 2016 Mar;17(1):27-33.
doi: 10.1007/s10195-015-0388-1. Epub 2015 Nov 14.

Effectiveness of intra-articular injections of sodium hyaluronate-chondroitin sulfate in knee osteoarthritis: a multicenter prospective study

Fabrizio Rivera  1   2 , Luca Bertignone  3   4 , Giancarlo Grandi  5 , Roberto Camisassa  5 , Guido Comaschi  6 , Diego Trentini  7 , Marco Zanone  8 , Giuseppe Teppex  8 , Gabriele Vasario  8 , Giorgio Fortina  9
Affiliations
Randomized Controlled Trial

Effectiveness of intra-articular injections of sodium hyaluronate-chondroitin sulfate in knee osteoarthritis: a multicenter prospective study

Fabrizio Rivera et al. J Orthop Traumatol. 2016 Mar.

Erratum in

Abstract

Background: Intra-articular injection of hyaluronic acid is a well-established therapy for the treatment of knee osteoarthritis. The aim of the study was to assess the effectiveness and safety of the use of Arthrum HCS(®) (40 mg hyaluronic acid and 40 mg chondroitin sulfate in 2 mL).

Materials and methods: This was an open, multicenter, prospective study. Men or women over 40 years of age with documented knee osteoarthritis and WOMAC subscore A (severity of pain) ≥25 were enrolled. They received three weekly intra-articular injections of sodium hyaluronate 2 % and chondroitin sulfate 2 % in combination. WOMAC subscore A was assessed at 1, 3 and 6 months after the last injection.

Results: One hundred and twelve patients were included (women, 66 %). The mean (SD) WOMAC subscore A decreased from 52.1 (15.2) at inclusion to 20.5 (19.7) at month 6 (P < 0.0001). The mean subscore was already significantly decreased 1 month after the last injection at 25.7 (P < 0.0001). Pain relief and consumption of analgesic drugs, both assessed with visual analogic scale (VAS), consistently decreased. The investigators were satisfied/very satisfied as regards the therapeutic effectiveness of sodium hyaluronate-chondroitin sulfate in reducing pain (77 %), improving mobility (78 %) and reducing the consumption of analgesics (74 %). Only one adverse effect was reported by one patient (knee tumefaction).

Conclusion: These results suggest that intra-articular injections of Arthrum HCS(®) (sodium hyaluronate plus chondroitin sulfate) in patients with knee osteoarthritis are efficient and safe. These results should be confirmed in a randomized controlled study.

Level of evidence: IV.

Keywords: Chondroitin sulfate; Intra-articular injection; Knee osteoarthritis; Sodium hyaluronate.

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Figures

Fig. 1
Fig. 1
Pain severity (WOMAC subscore A) after three injections of sodium hyaluronate-chondroitin sulfate in knee osteoarthritis
Fig. 2
Fig. 2
Overall assessment of efficacy of three injections of sodium hyaluronate-chondroitin sulfate in knee osteoarthritis by the investigator
See this image and copyright information in PMC

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