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. 2016 Jan 4;44(D1):D1069-74.
doi: 10.1093/nar/gkv1230. Epub 2015 Nov 17.

Therapeutic target database update 2016: enriched resource for bench to clinical drug target and targeted pathway information

Hong Yang  1 , Chu Qin  2 , Ying Hong Li  3 , Lin Tao  2 , Jin Zhou  3 , Chun Yan Yu  3 , Feng Xu  4 , Zhe Chen  5 , Feng Zhu  6 , Yu Zong Chen  7
Affiliations

Therapeutic target database update 2016: enriched resource for bench to clinical drug target and targeted pathway information

Hong Yang et al. Nucleic Acids Res. .

Abstract

Extensive drug discovery efforts have yielded many approved and candidate drugs targeting various targets in different biological pathways. Several freely accessible databases provide the drug, target and drug-targeted pathway information for facilitating drug discovery efforts, but there is an insufficient coverage of the clinical trial drugs and the drug-targeted pathways. Here, we describe an update of the Therapeutic Target Database (TTD) previously featured in NAR. The updated contents include: (i) significantly increased coverage of the clinical trial targets and drugs (1.6 and 2.3 times of the previous release, respectively), (ii) cross-links of most TTD target and drug entries to the corresponding pathway entries of KEGG, MetaCyc/BioCyc, NetPath, PANTHER pathway, Pathway Interaction Database (PID), PathWhiz, Reactome and WikiPathways, (iii) the convenient access of the multiple targets and drugs cross-linked to each of these pathway entries and (iv) the recently emerged approved and investigative drugs. This update makes TTD a more useful resource to complement other databases for facilitating the drug discovery efforts. TTD is accessible at http://bidd.nus.edu.sg/group/ttd/ttd.asp.

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Figures

Figure 1.
Figure 1.
The pathway affiliation search page of the therapeutic target database.
See this image and copyright information in PMC

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