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Review
. 2014 Apr;4(2):120-7.
doi: 10.1016/j.apsb.2014.02.005. Epub 2014 Mar 24.

Smart polymers for the controlled delivery of drugs - a concise overview

Honey Priya James  1 , Rijo John  1 , Anju Alex  1 , K R Anoop  1
Affiliations
Review

Smart polymers for the controlled delivery of drugs - a concise overview

Honey Priya James et al. Acta Pharm Sin B. 2014 Apr.

Abstract

Smart polymers have enormous potential in various applications. In particular, smart polymeric drug delivery systems have been explored as "intelligent" delivery systems able to release, at the appropriate time and site of action, entrapped drugs in response to specific physiological triggers. These polymers exhibit a non-linear response to a small stimulus leading to a macroscopic alteration in their structure/properties. The responses vary widely from swelling/contraction to disintegration. Synthesis of new polymers and crosslinkers with greater biocompatibility and better biodegradability would increase and enhance current applications. The most fascinating features of the smart polymers arise from their versatility and tunable sensitivity. The most significant weakness of all these external stimuli-sensitive polymers is slow response time. The versatility of polymer sources and their combinatorial synthesis make it possible to tune polymer sensitivity to a given stimulus within a narrow range. Development of smart polymer systems may lead to more accurate and programmable drug delivery. In this review, we discuss various mechanisms by which polymer systems are assembled in situ to form implanted devices for sustained release of therapeutic macromolecules, and we highlight various applications in the field of advanced drug delivery.

Keywords: Field sensitive polymers; Glucose responsive polymers; Smart polymers; Temperature responsive polymers; pH responsive polymers.

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Figures

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Graphical abstract
Figure 1
Figure 1
Various stimuli responsible for controlling drug release from smart polymeric drug delivery systems.
None
See this image and copyright information in PMC

References

    1. Ward MA, Georgiou TK. Thermoresponsive polymers for biomedical applications. Polymers. 2011;3:1215–1242.
    1. Kikuchi A, Okano T. Intelligent thermoresponsive polymeric stationary phases for aqueous chromatography of biological compounds. Prog Polym Sci. 2002;27:1165–1193.
    1. Hoffman AS, Stayton PS, Bulmus V, Chen GH, Chen JP, Cheung C. Really smart bioconjugates of smart polymers and receptor proteins. J Biomed Mater Res. 2000;52:577–586. - PubMed
    1. Al-Tahami K, Singh J. Smart polymer based delivery systems for peptides and proteins. Recent Pat Drug Deliv Formul. 2007;1:65–71. - PubMed
    1. Kumar A, Srivasthava A, Galevey IY, Mattiasson B. Smart polymers: physical forms and bioengineering applications. Prog Polym Sci. 2007;32:1205–1237.