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Comment
. 2015 Nov;88(5):938-40.
doi: 10.1038/ki.2015.259.

What is myeloperoxidase doing in ANCA-associated glomerulonephritis?

William G Couser  1 , Richard J Johnson  2
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Comment

What is myeloperoxidase doing in ANCA-associated glomerulonephritis?

William G Couser et al. Kidney Int. 2015 Nov.
Free article

Abstract

O'Sullivan et al. describe glomerular localization of myeloperoxidase (MPO) in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and correlate the amount of deposition with severity of injury. MPO is the antigen against which anti-MPO ANCAs are directed, the antigen to which pathogenic T cells that can induce antibody-independent AAV are directed, and MPO can induce glomerular injury directly by interacting with H2O2 and a halide to halogenate glomerular structures. All three of these roles are likely involved in human disease.

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